Results 61 to 70 of about 688,832 (367)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dynamic testing of complex structures [PDF]

open access: yes, 1973
Response of structure is determined under impulses large enough to create severe strains. Electrodynamic shaker can provide impulses to nearly any point on structure and can deliver repeated pulses of varying force and ...
Anderson, P., Birs, C.
core   +1 more source

Stationary and impulsive injection of electron beams in converging magnetic field [PDF]

open access: yes, 2009
In this work we study time-dependent precipitation of an electron beam injected into a flaring atmosphere with a converging magnetic field by considering collisional and Ohmic losses with anisotropic scattering and pitch angle diffusion.
Siversky, Taras V.   +1 more
core   +1 more source

impulse

open access: yes, 2000
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Philanthropy by Pakistani Diaspora in the USA [PDF]

open access: yes, 2005
Highlights from PCP's pioneering research study which seeks to understand the giving habits and philanthropic impulses of the Pakistani diaspora in the United States of ...

core  

Impulse distributions in dense granular flows: signatures of large-scale spatial structures

open access: yes, 2003
In this paper we report the results of simulations of a 2D gravity driven, dissipative granular flow through a hopper system. Measurements of impulse distributions P(I) on the simulated system show flow-velocity-invariant behavior of the distribution for
A Ferguson   +5 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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