Results 161 to 170 of about 15,904 (255)

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

open access: yesThe FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana   +4 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

open access: yesThe FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin   +2 more
wiley   +1 more source

From U to mnm⁵Se²U: tuning base pairing preferences through 2-chalcogen and 5-methylaminomethyl modifications. [PDF]

open access: yesSci Rep
Kuwerska P   +8 more
europepmc   +1 more source

Medium‐Cycle Fatigue Behavior of Three Metallic Materials and a Welded Steel Following Gaseous Hydrogen Soaking

open access: yesFatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT This study investigates the impact of hydrogen soaking on the medium‐cycle fatigue behavior of various metallic materials commonly used in gas transmission pipelines. The tested materials include ex‐service gray cast iron, ex‐service X52 carbon steel, brass, and welded X52 carbon steel.
E. Kufoin   +7 more
wiley   +1 more source

RF system model for In-band full duplex communications

open access: yes, 2016
Abstract. In recent years by increasing the demands for communication services various technologies are examined in order to improve the throughput and spectrum efficiency of the wireless communication systems. For improving the performance a communication network, system deficiencies such as transmitter and receiver impairments need to be removed or ...
openaire   +1 more source

Diagnosing Systemic Mastocytosis: State of the Art

open access: yesInternational Journal of Laboratory Hematology, EarlyView.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

Long-Range Allosteric Modulation of DNA Duplex Dynamics Induced by Pyrrole-Imidazole Polyamide Binding. [PDF]

open access: yesJ Phys Chem Lett
Kendall-Price SET   +7 more
europepmc   +1 more source

Unity or Distinction? Herman Bavinck’s Use of John Calvin and Later Reformed Orthodoxy in His Doctrine of the Two States

open access: yesInternational Journal of Systematic Theology, EarlyView.
Abstract This article examines the doctrine of Christ’s two states of humiliation and exaltation in Herman Bavinck’s and John Calvin’s thought, with the aim of illuminating Bavinck’s use of Calvin. The article begins by exploring Calvin’s use of the two states and argues that his treatment of Christ’s descent into hell is an important though ...
Sarah Killam Crosby
wiley   +1 more source

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