Results 51 to 60 of about 115,019,574 (294)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

State-of-the-Art in Parallel Computing with R [PDF]

, 2009
R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological advances drive increased use of simulations.
Hao Yu, Schmidberger, Markus, Tierney, Luke, Martin Morgan, Markus Schmidberger, Ulrich Mansmann, Luke Tierney, Eddelbuettel, Dirk, Yu, Hao, Dirk Eddelbuettel, Morgan, Martin, Mansmann, Ulrich   +11 more
core   +1 more source

MRAM-Based Analog Computing-In-Memory Macro With Reconfigurable In-Memory Reference ADC

IEEE Access
A compact $64\times 64$ magnetic RAM (MRAM)-based analog computing-in-memory (ACIM) macro is presented, co-optimizing in-memory techniques to overcome the inherently small read margin of MRAM-based ACIM.
Kyung Min Lee, Munhyeon Kim, Nameun Kang, Inhwan Lee, Jehun Lee, Joon Hwang, Jong-Ho Lee, Jae-Joon Kim   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Convolutional Echo‐State Network with Random Memristors for Spatiotemporal Signal Classification

Advanced Intelligent Systems, 2022
The unprecedented development of Internet of Things results in the explosion of spatiotemporal signals generated by smart edge devices, leading to a surge of interest in real‐time learning of such data.
Shaocong Wang, Hegan Chen, Woyu Zhang, Yi Li, Dingchen Wang, Shuhui Shi, Yaping Zhao, Kam Chi Loong, Xi Chen, Yujiao Dong, Yi Zhang, Yang Jiang, Chaudhry Furqan, Jia Chen, Qing Wang, Xiaoxin Xu, Guangyi Wang, Hongyu Yu, Dashan Shang, Zhongrui Wang   +19 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

New-Generation Ferroelectric AlScN Materials

Nano-Micro Letters
Highlights Ferroelectricity and domain dynamics of emerging ferroelectric AlScN films were discussed. The performance optimization of ferroelectric AlScN films grown by different deposition techniques was comprehensively analyzed.
Yalong Zhang, Qiuxiang Zhu, Bobo Tian, Chungang Duan   +3 more
doaj   +1 more source

Flash Memory Array for Efficient Implementation of Deep Neural Networks

Advanced Intelligent Systems, 2021
The advancement of artificial intelligence applications is promoted by developing deep neural networks (DNNs) with increasing sizes and putting forward higher computing power requirements of the processing devices.
Runze Han, Yachen Xiang, Peng Huang, Yihao Shan, Xiaoyan Liu, Jinfeng Kang   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source