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Computer memories: The history of computer form [PDF]
History and Technology, 1998 This paper looks at the computer as a truly global form. The similar beige boxes found in offices across the world are analysed from the perspective of design history rather than that of the history of science and technology. Through the exploration of an archive of computer manufacturer's catalogues and concurrent design texts, this paper examines the
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Instruction Set Architectures for Quantum Processing Units
, 2017 Progress in quantum computing hardware raises questions about how these devices can be controlled, programmed, and integrated with existing computational workflows.
AR Calderbank +3 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
New-Generation Ferroelectric AlScN Materials
Nano-Micro LettersHighlights Ferroelectricity and domain dynamics of emerging ferroelectric AlScN films were discussed. The performance optimization of ferroelectric AlScN films grown by different deposition techniques was comprehensively analyzed.
Yalong Zhang +3 more
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Self-rectifying resistive memory in passive crossbar arrays
Nature Communications, 2021 Memory-centric computing refers to computing designs where the memory, rather than the processor is central in the architecture. Here, the authors demonstrate a self-rectifying resistive memory cell that exhibits impressive endurance, and low power ...
Kanghyeok Jeon +7 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Scientific Reports, 2023 Reservoir computing is a brain heuristic computing paradigm that can complete training at a high speed. The learning performance of a reservoir computing system relies on its nonlinearity and short-term memory ability.
Zhiqiang Liao +5 more
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The Computational Nature of Memory Modification
eLife, 2016 Abstract Retrieving a memory can modify its influence on subsequent behavior. Whether this phenomenon arises from modification of the contents of the memory trace or its accessibility is a matter of considerable debate. We develop a computational theory that incorporates both mechanisms.
Samuel J Gershman +3 more
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, 2018 We investigate the use of interpolative separable density fitting (ISDF) as a means to reduce the memory bottleneck in auxiliary field quantum Monte Carlo (AFQMC) simulations of real materials in Gaussian basis sets.
Malone, Fionn D +2 more
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