Results 71 to 80 of about 931,753 (278)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Matrix Mapping on Crossbar Memory Arrays with Resistive Interconnects and Its Use in In-Memory Compression of Biosignals

Micromachines, 2019
Recent advances in nanoscale resistive memory devices offer promising opportunities for in-memory computing with their capability of simultaneous information storage and processing.
Yoon Kyeung Lee, Jeong Woo Jeon, Eui-Sang Park, Chanyoung Yoo, Woohyun Kim, Manick Ha, Cheol Seong Hwang   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Stateful In‐Memory Logic System and Its Practical Implementation in a TaOx‐Based Bipolar‐Type Memristive Crossbar Array

Advanced Intelligent Systems, 2020
Memristive stateful logic enables energy‐ and cost‐efficient in‐memory computing, which is desirable for edge computing in the coming Internet of Things  (IoT) era.
Young Seok Kim, Myeong Won Son, Hanchan Song, Juseong Park, Jangho An, Jae Bum Jeon, Geun Young Kim, Seoil Son, Kyung Min Kim   +8 more
doaj   +1 more source

Flexible and Stretchable Memristive Arrays for in-Memory Computing

Frontiers in Nanotechnology, 2022
With the tremendous progress of Internet of Things (IoT) and artificial intelligence (AI) technologies, the demand for flexible and stretchable electronic systems is rapidly increasing.
Xusheng Liu, Xusheng Liu, Jie Cao, Jie Cao, Jie Qiu, Xumeng Zhang, Xumeng Zhang, Xumeng Zhang, Ming Wang, Ming Wang, Qi Liu, Qi Liu, Qi Liu   +12 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Chaotic Compilation for Encrypted Computing: Obfuscation but Not in Name [PDF]

, 2019
An `obfuscation' for encrypted computing is quantified exactly here, leading to an argument that security against polynomial-time attacks has been achieved for user data via the deliberately `chaotic' compilation required for security properties in that ...
Breuer, Peter T.
core   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Atomic Layer-Deposited HfAlOx-Based RRAM with Low Operating Voltage for Computing In-Memory Applications

Nanoscale Research Letters, 2019
With Moore’s law closing to its physical limit, traditional von Neumann architecture is facing a challenge. It is expected that the computing in-memory architecture-based resistive random access memory (RRAM) could be a potential candidate to overcome ...
Zhen-Yu He, Tian-Yu Wang, Lin Chen, Hao Zhu, Qing-Qing Sun, Shi-Jin Ding, David Wei Zhang   +6 more
doaj   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source