Results 121 to 130 of about 1,063,217 (316)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

ENHANCEMENT FOR DATA SECURITY IN CLOUD COMPUTING ENVIRONMENT

, 2020
Cloud computing, a rapidly developing information technology, has aroused the concern of the whole world. Cloud computing is Internet-based computing, whereby shared resources, software and information, are provided to computers and devices on-demand ...
B., GAWALI M., WAGH, R. B., PATIL, S. P.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dynamic Batch Processing with FlexiDecode Scheduler for Efficient LLM Inference in IIoT

Big Data Mining and Analytics
Large Language Models (LLMs) are expanding their applications across various fields, including Industrial Internet of Things (IIoT), where they analyze sensor data, automate diagnostics, and enhance predictive maintenance.
Xiaocong Jia, Bruce Gu, Jinjun Chen, Longxiang Gao, Weiguang Pang, Guangtong Lv, Youyang Qu, Lei Cui   +7 more
doaj   +1 more source

Analysis of some key technical problems in the development of computing power network

Dianxin kexue, 2022
The current development status of domestic and foreign computing power network technology was introduced.The key technology of the computing power network was described.The problems which were encountered in the development and practice of the computing ...
Tao HE, Zhendong YANG, Chang CAO, Yan ZHANG, Xiongyan TANG   +4 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Vehicle Social Distancing Management System Based on LiFi During COVID Pandemic: Real-Time Monitoring for Smart Buildings

IEEE Access
The coronavirus (COVID-19) has emerged as one of the most serious issues. Researchers and officials are considering the implementation of several social distancing methods to detect potentially contaminated individuals.
Sallar S. Murad, Salman Yussof, Bha-Aldan Mundher Oraibi, Rozin Badeel, Banan Badeel, A. H. Alamoodi   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Unsupervised anomaly detection with memory bank and contrastive learning

Array
Using contrastive learning to optimize memory bank based storage features is an important issue in the field of image anomaly detection. Current memory-based anomaly detection methods, which are commonly based on pre-trained feature extractors ...
Min Li, Zuobin Ying, Gang Li, Mingle Zhou, Jinghui He   +4 more
doaj   +1 more source

The complexity of computations by networks

IBM Journal of Research and Development, 1987
Summary: We survey the current state of knowledge concerning the computation of Boolean functions by networks, with particular emphasis on the addition and multiplication of binary numbers.
openaire   +2 more sources