Results 141 to 150 of about 1,063,217 (316)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
IEEE AccessReliable trajectory similarity estimation underpins applications such as map matching, mobility anomaly detection, and travel behavior analysis. However, traditional distance-based methods are computationally expensive and sensitive to irregular sampling,
Fengqi Hao +6 more
doaj +1 more source
Intelligent Network Design Driven by Big Data Analytics, IoT, AI and Cloud Computing
, 2022 As enterprise access networks evolve with a larger number of mobile users, a wide range of devices and new cloud-based applications, managing user performance on an end-to-end basis has become rather challenging.
Mapp G., Cengiz K., Kumar S.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Adaptive Fixed-Time Tracking Control of Cart–Pendulum Robotic Systems with Bias Actuator Dynamics
ActuatorsThis research addresses the challenge of precise trajectory tracking for cart–pendulum robotic systems affected by unknown nonlinear actuator dynamics. We introduce a novel control framework that combines neural network modeling with adaptive parameter ...
Shuo Chen +3 more
doaj +1 more source
Cloud Computing: New Business Opportunities for Telecommunications Companies? [PDF]
Cloud computing has recently shifted into the center of attention of Telecommuications Companies. Deutsche Telekom, for example, just announced the importance of cloud computing as one of their leading growth sectors (Deutsche Telekom Press Release, 2010)
Kraemer, Jan +2 more
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Network and traffic engineering in emerging distributed computing applications [PDF]
, 2013 A distributed system consists of several autonomous computers that communicate through a computer network. Usually there is a common goal that all these networked computers try to achieve.
Mat Deris, Mustafa +4 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source