Results 81 to 90 of about 214,941 (307)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Examining the mediating and moderating role of psychological capital in the job demands-resources model

, 2014
Includes bibliographical references.Employee wellbeing has become a major concern for organisations globally, with an increased interest in the prevention of burnout and the maximisation of employee work engagement.
Brouze, Kim Lisa
core  

The Effect of Job Rotation on Employee Performance: The mediating role of HR strategy and training in the petrochemical industry [PDF]

Purpose - This study investigates the impact of job rotation on employee performance and explores the mediating role of HR strategy and training effectiveness on this relationship, within the petrochemical industry, which represents a highly specialist ...
Nasirifar, A., Majd, A., Bell, Robin, Ali, S., Bell, R, Davoodi, A., Alizadeh Majd, A   +6 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PENGARUH TOTAL REWARD TERHADAP JOB ENGAGEMENT SERTA DAMPAKNYA TERHADAP KINERJA PEGAWAI

MIX: Jurnal Ilmiah Manajemen, 2015
: Total Reward combines Transactional Reward and Relational Reward can meet any level of employee‘s needs therefore will foster employee to invest their Job involvement (cognitive energy), Job satisfaction (emotional reaction), Intrinsic motivation ...
Chresno Wahyu Widodo
doaj  

ANTECEDENTS OF BUDGETARY PARTICIPATION: ENHANCING EMPLOYEES’ JOB PERFORMANCE [PDF]

, 2013
his research investigated the antecedent budgetary participation (need for achievement and work attitude), then assess the impact on employees’ job performance. The data were obtained using questionnaires that distributed
Nikmah, Fatmawati
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

PERFORMANCE BASED PAY AS A DETERMINANT OF JOB SATISFACTION: A STUDY IN MALAYSIA GIATMARA CENTERS [PDF]

Compensation management literature highlights that performance based pay has two major characteristics: participation in pay systems and adequacy of pay.
Nurzawani ZAKARIA, Mohd Hamran MOHAMAD, Nurhana M RAFIUDDIN, Aniza WAMIN, Azman ISMAIL, Norashikin Sahol HAMID   +5 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Workplace Anxiety as a Bridge Between Job Insecurity and Work-Life Conflict: Insights from Healthcare Employees

Bulletin of Counseling and Psychotherapy
This research intends to examine the effect of role stress and job insecurity on job burnout and nurses' performance in hospitals. Apart from this, this research also explores the mediating role of workplace anxiety in the context of the bond between ...
Rohmawan Adi Pratama, Purwati Purwati, Indah Novita Sari, Ulfa Puspita Rachma, Filda Khoirun Nikmah   +4 more
doaj   +1 more source