Results 271 to 280 of about 497,128 (308)
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A comprehensive in silico analysis of sortase superfamily
Journal of Microbiology, 2019Sortases are cysteine transpeptidases that assemble surface proteins and pili in their cell envelope. Encoded by all Gram-positive bacteria, few Gram-negative bacteria and archaea, sortases are currently divided into six classes (A-F). Due to the steep increase in bacterial genome data in recent years, the number of sortase homologues have also ...
Adeel, Malik, Seung Bum, Kim
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Analysis of the proteome of Mycobacterium tuberculosis in silico
Tubercle and Lung Disease, 1999Novel bioinformatics routines have been used to provide a more detailed definition of the proteome of Mycobacterium tuberculosis H37Rv. Over half of the current proteins result from gene duplication or domain shuffling events while one-sixth show no similarity to polypeptides described in other organisms.
F, Tekaia +5 more
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In Silico Analysis of the Exome for Gene Discovery
2011Here we describe a bioinformatic strategy for extracting and analyzing the list of variants revealed from an exome sequencing project to identify potential disease genes. This in silico method filters out the majority of common SNPs and extracts a list of potential candidate protein-coding and non-coding RNA (ncRNA) genes.
Marcus, Hinchcliffe, Paul, Webster
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An in silico biomechanical analysis of the stent–esophagus interaction
Biomechanics and Modeling in Mechanobiology, 2017Despite all technological innovations in esophageal stent design over the past 20 years, the association between the stent design's mechanical behavior and its effect on the clinical outcome has not yet been thoroughly explored. A parametric numerical model of a commercially available esophageal bioresorbable polymeric braided wire stent is set up ...
Mathias Peirlinck +6 more
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In silico analysis of large microbial surface proteins
Research in Microbiology, 2007We analyzed the longest predicted proteins encoded in complete microbial genomes. They could be separated into two main classes: non-ribosomal peptide synthetases involved in secondary metabolism and surface proteins, many of them with a predicted or experimentally observed role in bacterial adhesion and biofilm formation.
Fátima, Yousef, Manuel, Espinosa-Urgel
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IN SILICO ANALYSIS OF P53 RESPONSE TO DNA DAMAGE
IFAC Proceedings Volumes, 2006Abstract p53 gene and its protein product play a key role in the cell's response to DNA damage. Approximately 50% of all human cancers displays p53 mutations, and in the vast majority of the other cases the gene's functionality is otherwise impaired.
LILLACCI, GABRIELE +2 more
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In silico analysis of pectin lyase and pectinase sequences
Biochemistry (Moscow), 2009A total of 48 full-length protein sequences of pectin lyases from different source organisms available in NCBI were subjected to multiple sequence alignment, domain analysis, and phylogenetic tree construction. A phylogenetic tree constructed on the basis of the protein sequences revealed two distinct clusters representing pectin lyases from bacterial ...
P K, Yadav +4 more
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Mutation Surveyor: An In Silico Tool for Sequencing Analysis
2011DNA sequencing is widely used for DNA diagnostics and functional studies of genes of interest. With significantly increased sequencing outputs, manual reading of sequence results can impede an efficient and accurate analysis. Mutation Surveyor is a useful in silico tool developed by SoftGenetics that assists the detection of sequence variations within ...
Chongmei, Dong, Bing, Yu
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In Silico Analysis of Squamous Cell Carcinoma
In silico methodology is discussed as a comprehensive approach to studying squamous cell carcinoma (SCC) and oral squamous cell carcinoma (OSCC). The advancement of computational methodologies has enabled the discovery of novel biomarkers by enhancing our understanding of tumor biology.openaire +2 more sources
In silico analysis of antifungal peptides.
Expert opinion on drug discovery, 2013Antimicrobial peptides are short peptides (< 100 amino acids) that have a potent function against microbial invasion. These peptides are produced by various organisms, including bacteria, fungi, flowering and non-flowering plants, insects and mammals.
Saeed, Soltani +2 more
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