Results 1 to 10 of about 497,029 (209)
Life, 2021 Multibody optimisation approaches have not seen much use in routine clinical applications despite evidence of improvements in modelling through a reduction in soft tissue artifacts compared to the standard gait analysis technique of direct kinematics. To
Claude Fiifi Hayford +4 more
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Frontiers in Molecular Biosciences, 2022 Coronaviruses are a great source of threat to public health which could infect various species and cause diverse diseases. However, the epidemic’s spreading among different species remains elusive.
Yanyan Zou +16 more
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Nature Communications, 2022 MEK1 mutations are found in cancer and RASopathies, but their effects remain unclear. Here, the authors reveal a mutant MEK1 structure and qualitative differences in biological properties between the cancer- and RASopathy-associated mutants, providing ...
Yuji Kubota +10 more
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In silico screening of non-synonymous SNPs in human TUFT1 gene
Journal of Genetic Engineering and Biotechnology, 2023 Background Tuftelin 1 (TUFT1) gene is important in the development and mineralization of dental enamel. The study aimed to identify potential functionally deleterious non-synonymous SNPs (nsSNPs) in the TUFT1 gene by using different in silico tools.
Athira Ajith, Usha Subbiah
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Journal of Tropical Life Science, 2023 Myxomycetes, commonly called plasmodial slime molds, are eukaryotic organisms usually thriving on terrestrial ecosystems, manifesting attributes of fungi and protists.
Christian Joseph Ong +5 more
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In silicoanalysis of trypanosomatids' helicases [PDF]
FEMS Microbiology Letters, 2012 Trypanosomatids are unicellular protozoan parasites that cause many diseases in animals, including humans, and plants. These early divergent eukaryotes have many singular structures and processes, including the hyper-modified 'base J', a mitochondrial DNA network, RNA editing, and trans-splicing; all of these unique features involve a wide variety of ...
Gargantini, Pablo Ruben +2 more
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PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]
, 2012 Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul +14 more
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Bioinformatic Resources for in Silico Proteome Analysis [PDF]
BioMed Research International, 2003 In the growing field of proteomics, tools for the in silico analysis of proteins and even of whole proteomes are of crucial importance to make best use of the accumulating amount of data. To utilise this data for healthcare and drug development, first the characteristics of proteomes of entire species—mainly the human—have to be understood, before ...
Pruess, Manuela, Apweiler, Rolf
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Bioinformatics analysis identified CDC20 as a potential drug target for cholangiocarcinoma [PDF]
PeerJ, 2021 Background Cholangiocarcinoma (CCA) is a malignancy that originates from bile duct cells. The incidence and mortality of CCA are very high especially in Southeast Asian countries. Moreover, most CCA patients have a very poor outcome. Presently, there are
Prin Sungwan +6 more
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In silico gene expression analysis – an overview [PDF]
Molecular Cancer, 2007 Abstract Efforts aimed at deciphering the molecular basis of complex disease are underpinned by the availability of high throughput strategies for the identification of biomolecules that drive the disease process. The completion of the human genome-sequencing project, coupled to major technological developments, has afforded investigators ...
MacMathuna Padraic +3 more
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