Comprehensive comparison of in silico MS/MS fragmentation tools of the CASMI contest: database boosting is needed to achieve 93% accuracy. [PDF]
, 2017 In mass spectrometry-based untargeted metabolomics, rarely more than 30% of the compounds are identified. Without the true identity of these molecules it is impossible to draw conclusions about the biological mechanisms, pathway relationships and ...
Biedendieck, Rebekka +11 more
core +2 more sources
Reproductive Biology and Endocrinology, 2022 Background Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency.
Fatemeh Afkhami +3 more
doaj +1 more source
Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs [PDF]
, 2013 Background: It was long assumed that proteins are at least 100 amino acids (AAs) long. Moreover, the detection of short translation products (e. g.
Baggerman, Geert +6 more
core +2 more sources
Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics. [PDF]
, 2018 The annotation of small molecules remains a major challenge in untargeted mass spectrometry-based metabolomics. We here critically discuss structured elucidation approaches and software that are designed to help during the annotation of unknown compounds.
Blaženović, Ivana +3 more
core +3 more sources
Cancer Cell International, 2019 Background Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent.
Bin Xu +6 more
doaj +1 more source
Sabiad, 2023 Objective: The TNF receptor gene 13B (TNFSRF13B) is a member of the TNF superfamily which is crucial for B cell maturation, plasma cell differentiation, and antibody response.
Sinem Fırtına +17 more
doaj +1 more source
A Novel Chimeric Antigen as a Vaccine Candidate against Leishmania major: In silico Analysis
Iranian Journal of Parasitology, 2021 Background: Leishmania is a mandatory intracellular pathogen and causing neglected disease. Hence, protection against leishmaniasis by a development vaccine is an important subject.
Niloofar Bavarsad Ahmadpour +3 more
doaj +1 more source
In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
core +5 more sources
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]
, 2020 Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim +7 more
core +2 more sources
IN-SILICO ANALYSIS; ANALYSIS OF S-303 BINDING TO CD-61 OF PLATELETS
THE PROFESSIONAL MEDICAL JOURNAL, 2016 ntroduction: Different pathogen reducing technologies are being implementedwhich includes S-303. CD-61 is important receptor for clotting. Pathogen reducing agents arebeing studied extensively to probe its effects. Objective: We conducted this study to reviewthe docking of S-303 at CD-61, to look into the effect of S-303 on function of platelets ...
Hammad Tufail Chaudhary, Shahida Hasnain
openaire +2 more sources