Results 1 to 10 of about 497,128 (308)

The Expression of OsPLA2-IIIand OsPPOGenes in Rice (Oryza sativaL.) Under Fe Toxicity Stress [PDF]

Journal of Tropical Life Science, 2021
Lipids are an important biomolecule in plants because of their structural and func-tional roles in plant cells. Moreover, they could act as signal molecules in the defense system of plants suffering from biotic and abiotic stresses ...
Turhadi, Hamim, Munif Ghulamahdi, Miftahudin   +3 more
doaj   +1 more source

Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy

Life, 2021
Multibody optimisation approaches have not seen much use in routine clinical applications despite evidence of improvements in modelling through a reduction in soft tissue artifacts compared to the standard gait analysis technique of direct kinematics. To
Claude Fiifi Hayford, Emma Pratt, John P. Cashman, Owain G. Evans, Claudia Mazzà   +4 more
doaj   +1 more source

Exploration of Potential Biomarker Genes and Pathways in Kawasaki Disease: An Integrated in-Silico Approach

Frontiers in Genetics, 2022
Kawasaki disease (KD) is a common childhood systemic vasculitis with a special predilection for coronary arteries. Even after more than five decades of the initial description of the disease, the etiology of KD remains an enigma.
Priyanka Srivastava, Chitra Bamba, Rakesh Kumar Pilania, Anu Kumari, Rajni Kumrah, Archan Sil, Surjit Singh   +6 more
doaj   +1 more source

In-Silico Analysis of Deleterious SNPs of FGF4 Gene and Their Impacts on Protein Structure, Function and Bladder Cancer Prognosis

Life, 2022
Dysregulation of fibroblast growth factors is linked to the pathogenesis of bladder cancer. The role of FGF1 and FGF3 is evident in bladder cancer; however, the role of FGF4 is vague.
Ee Chen Lim, Shu Wen Lim, Kenneth JunKai Tan, Maran Sathiya, Wan Hee Cheng, Kok-Song Lai, Jiun-Yan Loh, Wai-Sum Yap   +7 more
doaj   +1 more source

Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Nature Communications, 2022
MEK1 mutations are found in cancer and RASopathies, but their effects remain unclear. Here, the authors reveal a mutant MEK1 structure and qualitative differences in biological properties between the cancer- and RASopathy-associated mutants, providing ...
Yuji Kubota, Yuko Fujioka, Ashwini Patil, Yusuke Takagi, Daisuke Matsubara, Masatomi Iijima, Isao Momose, Ryosuke Naka, Kenta Nakai, Nobuo N. Noda, Mutsuhiro Takekawa   +10 more
doaj   +1 more source

In Silico Infection Analysis (iSFA) Identified Coronavirus Infection and Potential Transmission Risk in Mammals

Frontiers in Molecular Biosciences, 2022
Coronaviruses are a great source of threat to public health which could infect various species and cause diverse diseases. However, the epidemic’s spreading among different species remains elusive.
Yanyan Zou, Yanyan Zou, Xiaojian Cao, Xiaojian Cao, Bing Yang, Bing Yang, Lulu Deng, Lulu Deng, Yangyang Xu, Yangyang Xu, Shuang Dong, Wentao Li, Chengchao Wu, Chengchao Wu, Gang Cao, Gang Cao, Gang Cao   +16 more
doaj   +1 more source

Food Toxicity of Mycotoxin Citrinin and Molecular Mechanisms of Its Potential Toxicity Effects through the Implicated Targets Predicted by Computer-Aided Multidimensional Data Analysis

Life, 2023
The mycotoxin citrinin, which can contaminate food, is a major global concern. Citrinin is regarded as an inevitable pollutant in foods and feed since fungi are widely present in the environment.
Seema Zargar, Tanveer A. Wani
doaj   +1 more source

In silicoanalysis of trypanosomatids' helicases [PDF]

FEMS Microbiology Letters, 2012
Trypanosomatids are unicellular protozoan parasites that cause many diseases in animals, including humans, and plants. These early divergent eukaryotes have many singular structures and processes, including the hyper-modified 'base J', a mitochondrial DNA network, RNA editing, and trans-splicing; all of these unique features involve a wide variety of ...
Gargantini, Pablo Ruben, Lujan, Hugo Daniel, Pereira, Claudio Alejandro   +2 more
openaire   +3 more sources

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul, Balschun, Tobias, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Duerr, Richard H., Franke, Andre, Glas, Jürgen, Kamboh, M. Ilyas, Müller-Myhsok, Bertram, Olszak, Torsten, Pasciuto, Giulia, Seiderer, Julia, Wetzke, Martin, Wolf, Christiane   +14 more
core   +9 more sources

Mitochondrial mutations in protein coding genes of respiratory chain including complexes IV, V, and mt-tRNA genes are associated risk factors for congenital heart disease

EXCLI Journal : Experimental and Clinical Sciences, 2022
Most studies aiming at unraveling the molecular events associated with cardiac congenital heart disease (CHD) have focused on the effect of mutations occurring in the nuclear genome. In recent years, a significant role has been attributed to mitochondria
Mohammad Mehdi Heidari, Mehri Khatami, Akram Kamalipour, Mustafa Kalantari, Mahsa Movahed, Mohammad Hayet Emmamy, Mehdi Hadadzadeh, José Bragança, Mohsen Namnabat, Bahareh Mazrouei   +9 more
doaj   +1 more source