Results 71 to 80 of about 114,947,379 (306)

Cooperative load‐bearing characteristics of a pillar group and a gob pile in partially caved areas at shallow depth

Energy Science & Engineering, 2020
Stress concentration in partially caved goaf is the main cause of dynamic pressure accident in the lower seam mining. Aimed at the characteristics of caving in shallow partially caved goaf (PCG) and the specificity of interior load‐bearing structures, a ...
Defu Zhu, Xuanmin Song, Haocheng Li, Zhenghe Liu, Chen Wang, Yuming Huo   +5 more
doaj   +1 more source

In situ hybridization

Molecular and Cellular Probes, 1987
In situ hybridization is the hybridization-mediated detection of specific nucleic acid sequences within structurally intact cells or tissues. As such it uniquely provides localization of nucleic acid superimposed on observable cellular and subcellular structural detail, allowing analysis unobtainable by other hybridization techniques.
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mechanism of Fracture Evolution and the Mechanical Response of Coal Rock Composites

Applied Sciences
Understanding the mechanism of fracture evolution in underground stacked coal–rock composite structures is crucial for the accurate prediction and prevention of mine disasters.
Fengqi Guo, Weiguo Liang, Shengli Zhang, Wei He, Yongjun Yu, Zehan Zhang   +5 more
doaj   +1 more source

Architecture and Nation. The Schleswig Example, in comparison to other European Border Regions [PDF]

, 2019
Looking back at the five analyzed border regions, one might conclude that the relations between nation and nationality on one hand and architecture on the other hand demonstrate interesting similarities and differences.
Dragsbo, Peter, Peter Dragsbo
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The bed from the castle of Effiat in the Louvre museum [PDF]

, 2019
The bed which originally came from the Effiat chateau in the Puy-de-Dôme department and which is presented today in the Louvre, in the rooms of the department devoted to art objects, is well known as one of the rare surviving examples of a ‘French-style’
Agnès Bos, Bos, Agnès
core   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Convolutional model of rock failure prediction based on displacement coordination coefficient

Meitan kexue jishu
The study of rock stability state judgment and failure time prediction is of great significance for the prevention and control of coal mine dynamic disasters. To study the method of identifying the stable state of rocks and predicting the failure time, a
Weiyang LI, Yongxing SHEN, Zengchao FENG, Xuchen GUO, Hankui QI   +4 more
doaj   +1 more source