Results 61 to 70 of about 114,947,379 (306)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanism of mechanical strength degradation and microstructure evolution of anthracite induced by supercritical carbon dioxide

Meitan kexue jishu
In order to reveal the effect of supercritical carbon dioxide on the mechanical strength and microstructure of anthracite in the process of CO2 injection into deep coal seams, takes anthracite as the research object, the degradation characteristics of ...
Yichao JIA, Dong YANG, Xudong HUANG, Dingwei SUN, Liguo HE   +4 more
doaj   +1 more source

Editorial : In situ, revue de l’Inventaire général [PDF]

, 2012
Figure 1 Vierge à l’Enfant, statue en terre cuite entourée de François Lasa, photographe et de François Le Bœuf, chercheur, service régional de l’Inventaire en Pays-de-la-Loire Phot. Inv. F.
Verdier, Hélène
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Le patrimoine « in silico ». Exemple de la cathédrale d’Amiens [PDF]

, 2019
De nombreux projets en rapport avec la numérisation et la modélisation 3D de monuments historiques ont vu le jour ces dernières années, bénéficiant de l’accélération et de la fiabilisation des moyens techniques de relevé 3D et de traitement des données ...
Dominique Groux-Leclet, Guillaume Caron, Caron, Guillaume, Groux-Leclet, Dominique, Morbidi, Fabio, Fabio Morbidi, Mouaddib, El Mustapha, El Mustapha Mouaddib   +7 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Investigation into the Fracture Evolution Law of Overlying Strata Roof in Shallowly Buried “Three-Soft” Coal Seam Fully Mechanized Mining Faces and Its Influence on the Feasibility of Gob-Side Entry Retaining

Applied Sciences
To address the feasibility of gob-side entry retaining in the shallow-buried three-soft coal seam fully mechanized mining face (SB-TSCS FMMF) of Xindeng (Zhengzhou, China) Coal Industry, we established a mechanical model of post-mining roof–coal-rock ...
Guoyou Hu, Yongkang Yang, Shuai Li, Konghao Zhu   +3 more
doaj   +1 more source

Le patrimoine des Soieries Bonnet (Jujurieux, Ain) : conserver et valoriser in situ un ensemble unique de l’industrie textile [PDF]

, 2016
Le site et les collections des Soieries Bonnet à Jujurieux (Ain) constituent un ensemble exceptionnel, significatif de l’histoire de Lyon et de sa région aux XIXe et XXe siècles. À la cessation d’activité de l’entreprise fin 2001, les biens de la société
Nathalie Foron-Dauphin, sous la direction de Delphine Cano, Foron-Dauphin, Nathalie, Cano, sous la direction de Delphine   +3 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Study on mechanics and permeability evolution of sandy mudstone during full stress-strain loading

Meitan xuebao
The evolution law of surrounding rock pore crack and its permeability change during soft rock roadway excavation is one of the basic scientific problems to be solved in water inrush disaster prevention and grouting reinforcement of weak surrounding rock.
Zhaoyun CHAI, Xiaoling WU, Xiangyu LIU, Xu LIU, Yuxu SHEN, Zipeng XIN   +5 more
doaj   +1 more source