Results 61 to 70 of about 2,914,320 (305)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Device for in-situ cleaving of hard crystals [PDF]

, 2005
Cleaving crystals in a vacuum chamber is a simple method for obtaining atomically flat and clean surfaces for materials that have a preferential cleaving plane.
A. Renner, Eberhart M. E., F. J. Giessibl, Kim Y. -C., M. Schmid   +4 more
core   +2 more sources

Study on mechanics and permeability evolution of sandy mudstone during full stress-strain loading

Meitan xuebao
The evolution law of surrounding rock pore crack and its permeability change during soft rock roadway excavation is one of the basic scientific problems to be solved in water inrush disaster prevention and grouting reinforcement of weak surrounding rock.
Zhaoyun CHAI, Xiaoling WU, Xiangyu LIU, Xu LIU, Yuxu SHEN, Zipeng XIN   +5 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Mechanism of Fracture Evolution and the Mechanical Response of Coal Rock Composites

Applied Sciences
Understanding the mechanism of fracture evolution in underground stacked coal–rock composite structures is crucial for the accurate prediction and prevention of mine disasters.
Fengqi Guo, Weiguo Liang, Shengli Zhang, Wei He, Yongjun Yu, Zehan Zhang   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

In-situ Particle Acceleration in Collisionless Shocks [PDF]

, 2005
The outflows from gamma ray bursts, active galactic nuclei and relativistic jets in general interact with the surrounding media through collisionless shocks. With three dimensional relativistic particle-in-cell simulations we investigate such shocks. The
Frederiksen, J. T., Haugboelle, T., Hededal, C. B., Nordlund, Å.   +3 more
core   +3 more sources

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

In-Situ Thermal Remediation of Contaminated Soil [PDF]

, 2003
Recently, a method for removing contaminants from soil (several meters under the ground) has been proposed by McMillan-McGee Corp. The process can be described as follows.
Huang, Huaxiong, Lapin, Serguei, Westbrook, Rex   +2 more
core