Results 41 to 50 of about 83,691,994 (313)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Design of a Verification Device of Motor Axle Wheel Load Scales Based on Pump-Controlled Hydraulic Cylinder

Sensors
Vehicle axle load scales are one of the most important devices for vehicle safety testing. To ensure the stability and reliability of test results, regular calibration of axle load scales is necessary.
Long Hao, Zhipeng Xu, Bin Zhou, Gaoming Zhang   +3 more
doaj   +1 more source

Experimental Study on the Effect of Thermal Shock on Physical and Mechanical Properties of Limestone

Applied Sciences, 2023
Thermal shock is the physical process of rapid cooling of a hot object. The physical and mechanical properties of rocks that have undergone thermal shock will change.
Yunsheng Dong, Baoping Xi, Shuixin He, Luhai Chen   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Orthogonal optimization of the ratio of nano-silica sol-EVA-fly ash cement-based composite slurry and the effect on its physical properties

Meitan xuebao
To address the problem that traditional cement-based slurry materials cannot meet the actual demand for grouting and reinforcement of large deformation roadways in coal mines, some high-performance composite slurry materials are obtained by modifying ...
Yuxu SHEN, Zhaoyun CHAI, Haocheng SUN, Xiangyu LIU, Junqing GUO, Chang XIAO, Tianyu LI, Zipeng XIN, Qinbin SHI   +8 more
doaj   +1 more source

In situ hybridization

Molecular and Cellular Probes, 1987
In situ hybridization is the hybridization-mediated detection of specific nucleic acid sequences within structurally intact cells or tissues. As such it uniquely provides localization of nucleic acid superimposed on observable cellular and subcellular structural detail, allowing analysis unobtainable by other hybridization techniques.
openaire   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Rescue Path Planning and Simulation Analysis of Mining Robot Based on Improved A* Algorithm

Taiyuan Ligong Daxue xuebao
Purposes The situation of post-disaster site of coal mine underground is complex. Aiming at the fact that traditional A* algorithm-based coal mine robot rescue path planning bears path insecurity, low efficiency, and other problems, and by combining with
Biying DUAN, Zhaoyun CHAI, Zipeng XIN, Ke YAN, Chang XIAO, Xiangyu LIU, Tianyu LI, Xinyu LIU   +7 more
doaj   +1 more source

The bed from the castle of Effiat in the Louvre museum [PDF]

, 2019
The bed which originally came from the Effiat chateau in the Puy-de-Dôme department and which is presented today in the Louvre, in the rooms of the department devoted to art objects, is well known as one of the rare surviving examples of a ‘French-style’
Agnès Bos, Bos, Agnès
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source