Results 101 to 110 of about 768,241 (306)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Biobanking in forestry practices: towards an agency policy?

New Genetics and Society, 2018
The conservation-management of living beings is not only an issue in medicine. Based on a collaboration between a sociologist and a geneticist, this paper aims to document the banking practices in the sector of forest genetic resources, which raises ...
Fabien Milanovic, François Lefèvre
doaj   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

PGRFA Management of Outcrossing Plants Propagated by Seed: From On-Farm to Ex Situ Conservation and Some Italian Maize Case Studies

Agronomy
In this review, the main issues related to the conservation and valorization of Plant Genetic Resources for Food and Agriculture (PGRFA) will be primarily addressed.
Michela Landoni, Anna Bertoncini, Martina Ghidoli, Graziano Rossi, Elena Cassani, Sabrina Locatelli, Carlotta Balconi, Roberto Pilu   +7 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Uprooting Diversity? Peasant Farmers’ Market Engagements and the on-Farm Conservation of Crop Genetic Resources in the Guatemalan Highlands [PDF]

The long-term security of the global food supply is contingent upon the on-farm conservation of crop genetic diversity. Without it, food crops lack the ability to evolve in the face of new pests, emerging plant diseases, and changing environmental ...
S. Ryan Isakson
core  

Arkeolojik Alanda In situ (Yerinde) Mozaik Koruma Yöntemleri

Journal of Mosaic Research, 2012
The conservation of mosaics unearthed at excavations is evaluated according to the conditions in which they were buried / found and is generally classified, in terms of low, medium, or high level of deterioration in the mosaics.
Y. Selçuk Şener
doaj  

Survey on threatened medicinal plants diversity of Northwestern Syria

Genetic Resources
Throughout history, many plant species have been used as natural medicines to prevent and treat human diseases. Due to its geographical location, climate, and history, Syria contains a remarkable diversity of medicinal plants. However, in recent years a
Munzer Aldarvish, Anas Al Kaddour, Akram Bourgol, Yasser Ramazan, Yousef Hallak, Stephen Cavers , Joan Cottrell   +6 more
doaj   +1 more source

Comparative Oligo‐FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years

Advanced Science, EarlyView.
Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He, Hainan Zhao, Xiaoxue Zeng, Zujun Yang, Wenting Li, Guoyan Zhang, Guangrong Li, Jian He, Bin Guan, Jiming Jiang   +9 more
wiley   +1 more source

The nature and role of experiential knowledge for environmental conservation

, 2010
Understanding the nature and role of experiential knowledge for environmental conservation is a necessary step towards understanding if it should be used and how it might be applied with other types of knowledge in an evidence-based approach.
Fazey, Ioan Raymond Albert, Lindenmayer, David B., Dovers, Steve, Fazey, John A., Salisbury, Janet G.   +4 more
core   +1 more source