Results 241 to 250 of about 115,013,792 (297)
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content
Advanced Science, EarlyView.Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri +3 more
wiley +1 more source
Advanced Science, EarlyView.A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang +10 more
wiley +1 more source
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2017
This chapter focuses on in situ conservation. First, it defines in situ conservation and explains that it covers numerous active management techniques. The chapter looks at the aims of in situ management, which range from creating, restoring, protecting, and maintaining to improving and connecting.
Anne E. Goodenough, Adam G. Hart
openaire +1 more source
This chapter focuses on in situ conservation. First, it defines in situ conservation and explains that it covers numerous active management techniques. The chapter looks at the aims of in situ management, which range from creating, restoring, protecting, and maintaining to improving and connecting.
Anne E. Goodenough, Adam G. Hart
openaire +1 more source
2001
The Mediterranean Basin, especially the coastline and the semi-arid and arid rangelands, have in the recent past and are currently suffering acutely from human activities that result in genetic erosion. As discussed in earlier chapters, these activities include: increasing industrialization, pollution, urbanization, inadvertent fires, increasing ...
Nigel Maxted +3 more
openaire +1 more source
The Mediterranean Basin, especially the coastline and the semi-arid and arid rangelands, have in the recent past and are currently suffering acutely from human activities that result in genetic erosion. As discussed in earlier chapters, these activities include: increasing industrialization, pollution, urbanization, inadvertent fires, increasing ...
Nigel Maxted +3 more
openaire +1 more source
In Situ and Ex Situ Conservation of Chinese Plants
2020In total, 28,385 higher plants were distributed in the nature reserves, accounting for 77.0% of the total number of higher plants in China. Among them, there are 3842 species which are effectively protected; 2478 species are better protected. More than 84.4% endangered species grow in national and/or provincial natural reserves.
Xiaohua Jin, Hai Ren
openaire +1 more source
2017
This chapter looks into ex situ conservation. It acknowledges that in situ conservation techniques might be needed if a successful ex situ conservation programme, which is termed reintroduction, is achieved. The chapter explores the subdivisions of ex situ conservation: intensive or general captive breeding programmes and gene banks.
Anne E. Goodenough, Adam G. Hart
openaire +1 more source
This chapter looks into ex situ conservation. It acknowledges that in situ conservation techniques might be needed if a successful ex situ conservation programme, which is termed reintroduction, is achieved. The chapter explores the subdivisions of ex situ conservation: intensive or general captive breeding programmes and gene banks.
Anne E. Goodenough, Adam G. Hart
openaire +1 more source
2019
This chapter focuses on ex situ (off-site) conservation, which is the protection and management of biodiversity in artificial, human-built environments. Indeed, ex situ conservation allows wild-caught individuals to be maintained under close human supervision in facilities like zoos, aquariums, botanical gardens, or arboretums.
Bradley J. Cardinale +2 more
openaire +1 more source
This chapter focuses on ex situ (off-site) conservation, which is the protection and management of biodiversity in artificial, human-built environments. Indeed, ex situ conservation allows wild-caught individuals to be maintained under close human supervision in facilities like zoos, aquariums, botanical gardens, or arboretums.
Bradley J. Cardinale +2 more
openaire +1 more source
Conservation and Change: A Comparison of In situ and Ex situ Conservation of Jala Maize Germplasm
Crop Science, 2006Conservation of agricultural genetic resources, whether in situ (in farmers' fields) or ex situ (in a germplasm repository), provides variation for breeding and selection efforts. In this study, we assayed levels of genetic diversity from in situ and ex situ populations of Jala, a very tall, large‐eared race of maize (Zea mays L. subsp. mays), using 22
Elizabeth B. Rice +3 more
openaire +1 more source