Results 61 to 70 of about 620,275 (284)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Numerical simulation of waste landfill biodegradation: Fitting experimental data
DynaLandfill remains economically viable for the disposal of Municipal Solid Waste (MSW), however, experiences of failure in several Colombian and global locations, lead to soil, water, and air pollution, harming ecosystems, and biodiversity.
Vladimir Buelvas-Hernandez +2 more
doaj +1 more source
Artificial Intelligence in the Life Sciences, 2021 Accurate molecular property or activity prediction is one of the main goals in computer-aided drug design. Quantitative structure-activity relationship (QSAR) modeling and machine learning, more recently deep learning, have become an integral part of ...
Talia B. Kimber +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Improving route development using convergent retrosynthesis planning
Journal of CheminformaticsRetrosynthesis consists of recursively breaking down a target molecule to produce a synthesis route composed of readily accessible building blocks. In recent years, computer-aided synthesis planning methods have allowed a greater exploration of potential
Paula Torren-Peraire +5 more
doaj +1 more source
In silico estimates of the free energy rates in growing tumor spheroids [PDF]
, 2010 The physics of solid tumor growth can be considered at three distinct size scales: the tumor scale, the cell-extracellular matrix (ECM) scale and the sub-cellular scale. In this paper we consider the tumor scale in the interest of eventually developing a
Garikipati, K. +4 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Scientific ReportsCervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show ...
Anuraj Nayarisseri +12 more
doaj +1 more source
Risk and reward: extending stochastic glycaemic control intervals to reduce workload
BioMedical Engineering OnLine, 2020 Background STAR is a model-based, personalised, risk-based dosing approach for glycaemic control (GC) in critically ill patients. STAR provides safe, effective control to nearly all patients, using 1–3 hourly measurement and intervention intervals ...
Vincent Uyttendaele +4 more
doaj +1 more source
APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]
, 2019 Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie +8 more
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