Results 61 to 70 of about 621,467 (206)

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

In silico structural evaluation of short cationic antimicrobial peptides [PDF]

, 2018
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Cationic peptides with ...
Malkinson, John, Passarini, Ilaria, Rossiter, Sharon, Zloh, Mire   +3 more
core   +3 more sources

Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail

Scientific Reports, 2017
Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT).
Marwa M. Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E. Francis, Kim Van der Heiden, Victoria Ridger, Paul C. Evans   +12 more
doaj   +1 more source

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development

Journal of Cheminformatics, 2020
Risk assessment of newly synthesised chemicals is a prerequisite for regulatory approval. In this context, in silico methods have great potential to reduce time, cost, and ultimately animal testing as they make use of the ever-growing amount of available
Andrea Morger, Miriam Mathea, Janosch H. Achenbach, Antje Wolf, Roland Buesen, Klaus-Juergen Schleifer, Robert Landsiedel, Andrea Volkamer   +7 more
doaj   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +10 more sources

Kernel methods for in silico chemogenomics

, 2007
Predicting interactions between small molecules and proteins is a crucial ingredient of the drug discovery process. In particular, accurate predictive models are increasingly used to preselect potential lead compounds from large molecule databases, or to
Jacob, Laurent, Vert, Jean-Philippe
core   +1 more source

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain [PDF]

, 2019
The human pathogen Acinetobacter baumannii possesses high genetic plasticity and frequently acquires antimicrobial resistance genes. Here we investigated the role of natural transformation in these processes. Genomic DNA from different sources, including
Bahiense, Camila dos Santos, Bonomo, Robert A., Dotto, Cristian Marcelo, Fernandez, Jennifer, Iriarte, Andres, Melano, Roberto Gustavo, Montaña, Sabrina Daiana, Perez, Federico, Place, Kori, Ramirez, Maria Soledad, Soler Bistue, Alfonso J. C., Tolmasky, Marcelo E., Traglia, German Matias   +12 more
core   +1 more source

A longitudinal MRI dataset of brain metastases with tumor segmentations, clinical & radiomic data

Scientific Data
Brain metastases (BM) are a severe complication of multiple primary malignancies and constitute the most frequent tumors of the central nervous system.
Dimitra Flouri, Christos-Panagiotis Papanikas, Georgios C. Manikis, Eleftherios Ioannou, Georgia Karaoli, Elisavet Papageorgiou, Anastasia Constantinidou, Loizos Siakallis, Marilena Theodorou, Vasileios Vavourakis   +9 more
doaj   +1 more source

Genome-driven evolutionary game theory helps understand the rise of metabolic interdependencies in microbial communities [PDF]

, 2017
Metabolite exchanges in microbial communities give rise to ecological interactions that govern ecosystem diversity and stability. It is unclear, however, how the rise of these interactions varies across metabolites and organisms.
Segre, Daniel, Zomorrodi, Ali R.
core   +2 more sources

Recombination luminescence in N-type Czochralski silicon [PDF]

Recombination luminescence in Czochralski ...
Compton, W. D., Spry, R. J.
core   +1 more source