Results 111 to 120 of about 497,128 (308)
MLH1 gene: An in silico analysis
Journal of Computational Biology and Bioinformatics Research, 2013 The MLH1 gene responsible for colon cancer has been examined to identify functional consequences of single-nucleotide polymorphisms (SNPs). 16 SNPs have been identified in the MLH1 gene in which all are found to be nonsynonymous. Non synymous SNPs are relevant in many of the human inherited diseases since they change the aminoacid sequence of the ...
openaire +2 more sources
In silico Analysis and Site-directed Mutagenesis of Promoters
BIO-PROTOCOL, 2017 In normal as in cancerous cells, gene expression is tightly regulated by transcription factors, which are responsible for up- or down-regulation of thousands of targets involved in different cell processes. Transcription factors can directly regulate the expression of genes by binding to specific DNA sequences known as response elements. Identification
Salah Boudjadi, Jean-François Beaulieu
openaire +4 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling
Advanced Healthcare Materials, EarlyView.Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee +7 more
wiley +1 more source
Genome-Wide Analysis of Eucalyptus grandis YABBY Transcription Factors
Türkiye Tarımsal Araştırmalar Dergisi, 2018 YABBY gene family is one of the plant transcription factors. The aim of this study was to characterize and define the YABBY gene family members in silico, in Eucalyptus grandis genome. In this study, various in silico methods was used.
Emre İLHAN
doaj +1 more source
Gastrointestinal endogenous proteins as a source of bioactive peptides : Doctor of Philosophy in Nutritional Sciences at Riddet Institute, Massey University, Palmerston North, New Zealand [PDF]
, 2016 Gastrointestinal endogenous proteins (GEP) were investigated as a source of bioactive peptides. In silico and in vitro methods were used singly or in combination to study GEP-derived peptides after simulated digestion.
Acharya, Prasannalakshmi
core
A comparative in-silico analysis of autophagy proteins in ciliates
PeerJ, 2017 Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called autophagy-related genes ( ATG s)
Aslan, Erhan +2 more
openaire +3 more sources
Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals
Advanced Healthcare Materials, EarlyView.Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar +4 more
wiley +1 more source
Optimizing human pulmonary perfusion measurement using an in silico model of arterial spin labeling magnetic resonance imaging. [PDF]
, 2019 Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is an imaging methodology that uses blood as an endogenous contrast agent to quantify flow.
Addo, Daniel A +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales +12 more
wiley +1 more source