Results 101 to 110 of about 98,414 (282)

Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors

Frontiers in Bioengineering and Biotechnology, 2020
The survival rate of patients with breast cancer has been improved by immune checkpoint blockade therapies, and the efficacy of their combinations with epigenetic modulators has shown promising results in preclinical studies.
Hanwen Wang, Richard J. Sové, Mohammad Jafarnejad, Sondra Rahmeh, Elizabeth M. Jaffee, Elizabeth M. Jaffee, Vered Stearns, Evanthia T. Roussos Torres, Roisin M. Connolly, Roisin M. Connolly, Aleksander S. Popel, Aleksander S. Popel   +11 more
doaj   +1 more source

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors [PDF]

, 2015
Following our recent study of N-(β-D-glucopyranosyl)-oxadiazole-carboxamides (Polyák et al., Biorg. Med. Chem. 2013, 21, 5738) revealed as moderate inhibitors of glycogen phosphorylase (GP), in silico docking calculations using Glide have been performed ...
Alex, Arunan, Benltifa, Bokor, Broggini, Brownlee, Carta, Cheng, Cho, Chrysina, Condi, Danaei, Docsa, Fischer, Francl, Friesner, Hayes, Hayes, Hehre, Huisgen, Huisgen, Huisgen, Jorgensen, Jorgensen, Kaminski, Kantsadi, Kantsadi, Kenny, Koldobskii, Kun, Lagorce, Lipinski, Lonsdale, Marten, Murray, Murray, Nagy, Nagy, Oikonomakos, Paolini, Polya, Polyák, Pospisil, Potts, Potts, Smith, Somsák, Somsák, Somsák, Somsák, Still, Tannor, Veber, Woon, Zhao, Zhong, Zhou, Ősz   +57 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Neospora caninum and Bovine Neosporosis: Current Vaccine Research [PDF]

, 2017
Neospora caninum, a tissue cyst-forming parasite, is the causative agent of bovine neosporosis. It is considered to be one of the most important transmissible causes of reproductive failure in cattle; abortion and neonatal mortality result in significant
Marugan-Hernandez, V
core   +2 more sources

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery

Frontiers in Drug Delivery
A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy of nanosystem-based intravascular drug delivery (IVDD).
Nicolae-Viorel Buchete, Nicolae-Viorel Buchete, Iwona Cicha, Sutapa Dutta, Sutapa Dutta, Panagiotis Neofytou   +5 more
doaj   +1 more source

In vitro and in silico Approaches to Study Cytochrome P450-Mediated Interactions

Journal of Pharmacy & Pharmaceutical Sciences, 2018
In vitro and in silico models of drug metabolism are utilized regularly in the drug research and development as tools for assessing pharmacokinetic variability and drug-drug interaction risk. The use of in vitro and in silico predictive approaches offers
Boon Hooi Tan, Yan Pan, Amelia Nathania Dong, Chin Eng Ong   +3 more
doaj   +1 more source

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals

Advanced Healthcare Materials, EarlyView.
Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar, Judith Evers, Alexandre Trotier, Manus Biggs, Madeleine M. Lowery   +4 more
wiley   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

In silico Clinical Trials: a vision of the future

, 2018
Slides of my talk at the VPH2018 conference in Zaragoza, entitled "In silico Clinical Trials: a vision of the future".
openaire   +1 more source