Results 1 to 10 of about 112,241 (141)

In-Silico Trials for Treatment of Acute Ischemic Stroke [PDF]

Frontiers in Neurology, 2020
Despite improved treatment, a large portion of patients with acute ischemic stroke due to a large vessel occlusion have poor functional outcome. Further research exploring novel treatments and better patient selection has therefore been initiated.
Praneeta R. Konduri, Praneeta R. Konduri, Henk A. Marquering, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie, The INSIST Investigators   +7 more
doaj   +4 more sources

Novel Baseline Facial Muscle Database Using Statistical Shape Modeling and In Silico Trials toward Decision Support for Facial Rehabilitation [PDF]

Bioengineering, 2023
Backgrounds and Objective: Facial palsy is a complex pathophysiological condition affecting the personal and professional lives of the involved patients.
Vi-Do Tran, Tan-Nhu Nguyen, Abbass Ballit, Tien-Tuan Dao   +3 more
doaj   +2 more sources

In Silico Trials of Prosthetic Valves Replicate Methodologies for Evaluating the Fatigue Life of Artificial Leaflets to Expand Beyond In Vitro Tests and Conventional Clinical Trials [PDF]

Biomedicines
Background: Fatigue failure of artificial leaflets significantly limits the durability of prosthetic valves. However, the costs and complexities associated with in vitro testing and conventional clinical trials to investigate the fatigue life of leaflets
Pengzhi Mao, Min Jin, Wei Li, Haitao Zhang, Haozheng Li, Shilong Li, Yuting Yang, Minjia Zhu, Yue Shi, Xuehuan Zhang, Duanduan Chen   +10 more
doaj   +2 more sources

Generation of a Virtual Cohort of Patients for in Silico Trials of Acute Ischemic Stroke Treatments

Applied Sciences, 2023
The development of in silico trials based on high-fidelity simulations of clinical procedures requires the availability of large cohorts of three-dimensional (3D) patient-specific anatomy models, which are often hard to collect due to limited ...
Sara Bridio, Giulia Luraghi, Anna Ramella, Jose Felix Rodriguez Matas, Gabriele Dubini, Claudio A. Luisi, Michael Neidlin, Praneeta Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B. L. M. Majoie, Francesco Migliavacca   +11 more
doaj   +3 more sources

Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction

Frontiers in Toxicology, 2022
The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery.
Cristian Trovato, Marcel Mohr, Friedemann Schmidt, Elisa Passini, Blanca Rodriguez   +4 more
doaj   +3 more sources

In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials

Nature Communications, 2021
In-silico trials rely on virtual populations and interventions simulated using patient-specific models and may offer a solution to lower costs. Here, the authors present the flow diverter performance assessment in-silico trial, which models the treatment
Ali Sarrami-Foroushani, Toni Lassila, Michael MacRaild, Joshua Asquith, Kit C. B. Roes, James V. Byrne, Alejandro F. Frangi   +6 more
doaj   +2 more sources

Digital twins, synthetic patient data, and in-silico trials: can they empower paediatric clinical trials? [PDF]

The Lancet: Digital Health
Summary: Randomised controlled trials are the gold standard to assess the effectiveness and safety of clinical interventions; however, many paediatric trials are discontinued early due to challenges in patient enrolment.
ProfMD Mohan Pammi, Prakesh S Shah, MD, Liu K Yang, PhD, Joseph Hagan, ScD, Nima Aghaeepour, PhD, ProfMD Josef Neu, PhD   +5 more
doaj   +2 more sources

Doxorubicin PK/PD modeling in multiple myeloma: towards in silico trials [PDF]

Biology Direct
Doxorubicin (DOXO) is a well-known chemotherapy drug, which is widely used in the treatment of Multiple Myeloma (MM), a treatable but not curable type of blood cancer.
Daniele Andrean, Francesco Da Ros, Mario Mazzucato, Morten Gram Pedersen, Roberto Visentin   +4 more
doaj   +2 more sources

Exploring the Potential of Generative Adversarial Networks for Synthesizing Radiological Images of the Spine to be Used in In Silico Trials

Frontiers in Bioengineering and Biotechnology, 2018
In silico trials recently emerged as a disruptive technology, which may reduce the costs related to the development and marketing approval of novel medical technologies, as well as shortening their time-to-market.
Fabio Galbusera, Frank Niemeyer, Maike Seyfried, Tito Bassani, Gloria Casaroli, Annette Kienle, Hans-Joachim Wilke   +6 more
doaj   +3 more sources

In-silico trials of targeted screening for abdominal aortic aneurysms using linked healthcare data: A study protocol. [PDF]

PLoS ONE
BackgroundThe NHS abdominal aortic aneurysm (AAA) screening programme (NAAASP) is both clinically and economically effective. One of the main determinants of this effectiveness is disease prevalence.
Liam Musto, Athanasios Saratzis, Mintu Nath, Emmanuel Katsogridakis, Ann Elsworth, Sylwia Bujkiewicz, Clark Hobson, Claire Lawson, Susan Wallace, Maria Gonzalez-Aguado, Aiden Smith, Susan Hodgson, Guiqing Lily Yao, José Miola, Matthew J Bown   +14 more
doaj   +2 more sources