Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents
Current Research in Pharmacology and Drug Discovery, 2022 Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists.
Nilesh Gajanan Bajad +4 more
doaj +1 more source
A systematic review of cardiac in-silico clinical trials
Progress in Biomedical Engineering, 2023 Abstract Computational models of the heart are now being used to assess the effectiveness and feasibility of interventions through in-silico clinical trials (ISCTs). As the adoption and acceptance of ISCTs increases, best practices for reporting the methodology and analysing the results will emerge. Focusing in the area of cardiology, we
Cristobal Rodero +7 more
openaire +4 more sources
Computational and Structural Biotechnology Journal, 2022 Immunotoxicity hazard identification of chemicals aims to evaluate the potential for unintended effects of chemical exposure on the immune system. Perfluorinated alkylate substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic ...
Francesco Pappalardo +4 more
doaj +1 more source
Computational modelling and simulation for immunotoxicity prediction induced by skin sensitisers
Computational and Structural Biotechnology Journal, 2022 In many domains regulating chemicals and chemical products, there is a legal requirement to determine skin sensitivity to allergens. While many in vitro assays to detect contact hypersensitivity have been developed as alternatives to animal testing over ...
Giulia Russo +6 more
doaj +1 more source
Exploring the Power and Promise of In Silico Clinical Trials with Application in COVID-19 Infection
Sudan Journal of Medical Sciences, 2021 Background: COVID-19 pandemic has dramatically engulfed the world causing catastrophic damage to human society. Several therapeutic and vaccines have been suggested for the disease in the past months, with over 150 clinical trials currently running or ...
Abdelrahman H. Abdelmoneim +4 more
doaj +1 more source
Preclinical Models: Boosting Synergies for Improved Translation [PDF]
, 2020 The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...
Attanasio C., Sangiovanni M.
core +1 more source
Ayurvedic formulations: Potential COVID-19 therapeutics?
Phytomedicine Plus, 2022 Background: While Molnupiravir and Paxlovid have recently been approved for use in some countries, there are no widely available treatments for COVID-19, the disease caused by SARS-CoV-2 infection.
Anees Ahmed Mahaboob Ali +3 more
doaj +1 more source
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]
, 2019 Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine +16 more
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Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE) [PDF]
, 2014 The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu) project is funded by the European Commission within the 7th Framework Programme.
Ambrušová, Katarína +9 more
core +1 more source
Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem +3 more
core +5 more sources