Results 1 to 10 of about 98,414 (282)

Synthetic biomedical data generation in support of In Silico Clinical Trials [PDF]

Frontiers in Big Data, 2023
Living in the era of Big Data, one may advocate that the additional synthetic generation of data is redundant. However, to be able to truly say whether it is valid or not, one needs to focus more on the meaning and quality of data than on the quantity ...
Alena Simalatsar, Alena Simalatsar, Alena Simalatsar   +2 more
doaj   +4 more sources

In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim [PDF]

BMC Medical Informatics and Decision Making, 2022
Background The last few decades have seen the approval of many new treatment options for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic methodology and criteria.
Fianne L. P. Sips, Francesco Pappalardo, Giulia Russo, Roberta Bursi   +3 more
doaj   +4 more sources

Credibility assessment of in silico clinical trials for medical devices. [PDF]

PLoS Computational Biology
In silico clinical trials (ISCTs) are an emerging method in modeling and simulation where medical interventions are evaluated using computational models of patients.
Pras Pathmanathan, Kenneth Aycock, Andreu Badal, Ramin Bighamian, Jeff Bodner, Brent A Craven, Steven Niederer   +6 more
doaj   +4 more sources

In-Silico Trials for Treatment of Acute Ischemic Stroke

Frontiers in Neurology, 2020
Despite improved treatment, a large portion of patients with acute ischemic stroke due to a large vessel occlusion have poor functional outcome. Further research exploring novel treatments and better patient selection has therefore been initiated.
Praneeta R. Konduri, Praneeta R. Konduri, Henk A. Marquering, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie, The INSIST Investigators   +7 more
doaj   +3 more sources

The Virtual Anemia Trial: An Assessment of Model‐Based In Silico Clinical Trials of Anemia Treatment Algorithms in Patients With Hemodialysis [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2018
In silico approaches have been proposed as a novel strategy to increase the repertoire of clinical trial designs. Realistic simulations of clinical trials can provide valuable information regarding safety and limitations of treatment protocols and have ...
Doris H. Fuertinger, Alice Topping, Franz Kappel, Stephan Thijssen, Peter Kotanko   +4 more
doaj   +2 more sources

A Step‐by‐Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models [PDF]

CPT: Pharmacometrics & Systems Pharmacology
In silico clinical trials (ISCT) are computational frameworks that employ mathematical models to generate virtual patients and simulate their responses to new treatments, treatment regimens, or medical devices via simulations mirroring real‐world ...
Javiera Cortés‐Ríos, Mindy Magee, Anna Sher, William J. Jusko, Rajat Desikan   +4 more
doaj   +2 more sources

Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction

Frontiers in Toxicology, 2022
The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery.
Cristian Trovato, Marcel Mohr, Friedemann Schmidt, Elisa Passini, Blanca Rodriguez   +4 more
doaj   +3 more sources

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Frontiers in Physiology, 2017
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction.
Elisa Passini, Oliver J. Britton, Hua Rong Lu, Jutta Rohrbacher, An N. Hermans, David J. Gallacher, Robert J. H. Greig, Alfonso Bueno-Orovio, Blanca Rodriguez   +8 more
doaj   +3 more sources

Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents

Current Research in Pharmacology and Drug Discovery, 2022
Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists.
Nilesh Gajanan Bajad, Sudhir Kumar Singh, Sushil Kumar Singh, Tryambak Deo Singh, Meenakshi Singh   +4 more
doaj   +1 more source

Exploring the Power and Promise of In Silico Clinical Trials with Application in COVID-19 Infection

Sudan Journal of Medical Sciences, 2021
Background: COVID-19 pandemic has dramatically engulfed the world causing catastrophic damage to human society. Several therapeutic and vaccines have been suggested for the disease in the past months, with over 150 clinical trials currently running or ...
Abdelrahman H. Abdelmoneim, Safinaz I. Khalil, Hiba Awadelkareem Osman Fadl, Ayesan Rewane, Sahar G. Elbager   +4 more
doaj   +1 more source