In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
core +5 more sources
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions [PDF]
, 2018 Accepted for publication in a future issue of Future Medicinal Chemistry.The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative ...
Blomberg N +6 more
core +2 more sources
Complete populations of virtual patients forin silicoclinical trials
Bioinformatics, 2020 AbstractMotivationModel-based approaches to safety and efficacy assessment of pharmacological drugs, treatment strategies or medical devices (In Silico Clinical Trial, ISCT) aim to decrease time and cost for the needed experimentations, reduce animal and human testing, and enable precision medicine. Unfortunately, in presence of non-identifiable models
S Sinisi +4 more
openaire +4 more sources
Microfluidic technology and simulation models in studying pharmacokinetics during pregnancy
Frontiers in Pharmacology, 2023 Introduction: Preterm birth rates and maternal and neonatal mortality remain concerning global health issues, necessitating improved strategies for testing therapeutic compounds during pregnancy.
Ananth K. Kammala +5 more
doaj +1 more source
BMC Bioinformatics, 2019 Background Tuberculosis (TB) represents a worldwide cause of mortality (it infects one third of the world’s population) affecting mostly developing countries, including India, and recently also developed ones due to the increased mobility of the world ...
Marzio Pennisi +11 more
doaj +1 more source
Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature update [PDF]
, 2019 The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery.
Garnett, Martin C. +3 more
core +3 more sources
Ten‐Year Simulation of the Effects of Denosumab on Bone Remodeling in Human Biopsies
JBMR Plus, 2021 Postmenopausal osteoporosis is a disease manifesting in degradation of bone mass and microarchitecture, leading to weakening and increased risk of fracture.
Duncan C Tourolle +6 more
doaj +1 more source
Engineering simulations for cancer systems biology [PDF]
, 2012 Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses.
Andrews, Paul S. +8 more
core +4 more sources
Modelling of Tirapazamine effects on solid tumour morphology [PDF]
, 2011 Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive ...
A.I. Minchinton +18 more
core +2 more sources
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]
, 2019 Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core +2 more sources