Preclinical Models: Boosting Synergies for Improved Translation [PDF]
, 2020 The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...
Attanasio C., Sangiovanni M.
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Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem +3 more
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Bayesian Augmented Clinical Trials in TB Therapeutic Vaccination
Frontiers in Medical Technology, 2021 We propose a Bayesian hierarchical method for combining in silico and in vivo data onto an augmented clinical trial with binary end points. The joint posterior distribution from the in silico experiment is treated as a prior, weighted by a measure of ...
Dimitrios Kiagias +4 more
doaj +1 more source
In Silico Model Estimates the Clinical Trial Outcome of Cancer Vaccines [PDF]
Cells, 2021 Over 30 years after the first cancer vaccine clinical trial (CT), scientists still search the missing link between immunogenicity and clinical responses. A predictor able to estimate the outcome of cancer vaccine CTs would greatly benefit vaccine development. Published results of 94 CTs with 64 therapeutic vaccines were collected.
Orsolya Lőrincz +8 more
openaire +3 more sources
In silico clinical trials: how computer simulation will transform the biomedical industry [PDF]
, 2016 The term ‘in silico clinical trials indicates the use of individualised computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention.
Henney, A. +2 more
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New Microbes and New Infections, 2020 Randomized clinical trials are not relevant for infectious disease outbreaks due to a new pathogen, for which public health decisions have to be made urgently.
P. Gautret, D. Raoult
doaj +1 more source
Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging
Scientific Reports, 2023 Stroke simulations are needed to run in-silico trials, develop hypotheses for clinical studies and to interpret ultrasound monitoring and radiological imaging.
James P. Hague +5 more
doaj +1 more source
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]
, 2019 Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine +16 more
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In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. [PDF]
, 2016 The long-term overall survival of Ewing sarcoma (EWS) patients remains poor; less than 30% of patients with metastatic or recurrent disease survive despite aggressive combinations of chemotherapy, radiation and surgery.
Alturkmani, Hani +11 more
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The promise of cardiomyocyte computational models for drug safety [PDF]
Military Medical ResearchLei Wang, Blanca Rodriguez
doaj +2 more sources