Results 31 to 40 of about 98,414 (282)

Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. [PDF]

, 2013
A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various
Hunt, C. Anthony, Hunt, CA, Kennedy, RC, Kim, SHJ, Ropella, GEP   +4 more
core   +2 more sources

In silico assessment of biomedical products: the conundrum of rare but not so rare events in two case studies [PDF]

, 2017
In silico clinical trials, defined as “The use of individualized computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention,” have been proposed as a possible strategy to reduce the ...
Adam Himes, American Diabetes Association, Anderson SM, Andreassen S, Bassingthwaighte JB, Bassingthwaighte JB, Basu R, Baxter W, Benson N, Bode BW, Boris Kovatchev, Bosi GM, Bosmans L, Britten RD, Campbell MP, Carriero A, Chen L, Christie GR, Claudio Cobelli, Cobelli C, Cobelli C, Cooling MT, Cristofolini L, Dalla Man C, Danaei G, DiMasi JA, El Makssoud H, Falcinelli C, Fernandez JW, Fernandez JW, Fregly BJ, Fritsch A, Gasser TC, Ghanbari J, Haddad T, Haddad T, Hamed E, Heidlauf T, Hinshaw L, Hunter PJ, Kennergren C, Kohout J, Kovatchev BP, Kropff J, Krueger MW, Lavagnino M, Lehmann ED, Leone-Bay A, Li X, Li X, Lloyd CM, Lodola A, Lungu A, Maceri F, Mah JT, Marco Viceconti, Mark Palmer, Martelli S, Martelli S, Martelli S, Meagher JM, Morris PD, Nair KS, Nørgaard BL, Oberhofer K, Panteleon AE, Porzio S, Predoi-Racila M, Qasim M, Ravera EP, Renard E, Riccio AI, Salzsieder E, Scheys L, Scheys L, Shaw JE, Shim VB, Smith DW, Smith N, Sorensen JT, Srinivasan R, Steil GM, Swee JKY, Szczesny SE, Tarek Haddad, The Diabetes Control and Complications Trial Research Group, Toffanin C, UK Prospective Diabetes Study Group (UKPDS), Vettoretti M, Viceconti M, Viceconti M, Visentin R, Visentin R, Visentin R, Visentin R, Weis JA, Zarins CK, Zimmet P   +97 more
core   +1 more source

In silico clinical trials: concepts and early adoptions

Briefings in Bioinformatics, 2018
Abstract Innovations in information and communication technology infuse all branches of science, including life sciences. Nevertheless, healthcare is historically slow in adopting technological innovation, compared with other industrial sectors. In recent years, new approaches in modelling and simulation have started to provide important
Francesco Pappalardo 0001, Giulia Russo, Flora Musuamba Tshinanu, Marco Viceconti   +3 more
openaire   +2 more sources

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]

, 2020
Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim, De Spiegelaere, Ward, Kinloch-de Loes, Sabine, Kint, Sam, Malatinková, Eva, Trypsteen, Wim, Van Criekinge, Wim, Vandekerckhove, Linos   +7 more
core   +2 more sources

Moving forward through the in silico modeling of multiple sclerosis: Treatment layer implementation and validation

Computational and Structural Biotechnology Journal, 2023
Multiple sclerosis is an autoimmune inflammatory disease that affects the central nervous system through chronic demyelination and loss of oligodendrocytes.
Avisa Maleki, Elena Crispino, Serena Anna Italia, Valentina Di Salvatore, Maria Assunta Chiacchio, Fianne Sips, Roberta Bursi, Giulia Russo, Davide Maimone, Francesco Pappalardo   +9 more
doaj   +1 more source

Establishing combination PAC‐1 and TRAIL regimens for treating ovarian cancer based on patient‐specific pharmacokinetic profiles using in silico clinical trials

Computational and Systems Oncology, 2022
Ovarian cancer is commonly diagnosed in its late stages, and new treatment modalities are needed to improve patient outcomes and survival. We have recently established the synergistic effects of combination tumor necrosis factor‐related apoptosis ...
Olivia Cardinal, Chloé Burlot, Yangxin Fu, Powel Crosley, Mary Hitt, Morgan Craig, Adrianne L. Jenner   +6 more
doaj   +1 more source

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Frontiers in Pharmacology, 2021
Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism ...
Jeremiah Oshiomame Unuofin, Nelisiwe Prenate Masuku, Oluwatomiwa Kehinde Paimo, Sogolo Lucky Lebelo   +3 more
doaj   +1 more source

Optimizing radiation therapy treatments by exploring tumour ecosystem dynamics in-silico [PDF]

, 2019
In this contribution, we propose a system-level compartmental population dynamics model of tumour cells that interact with the patient (innate) immune system under the impact of radiation therapy (RT).
Fellermann, Harold, Scheidegger, Stephan
core   +1 more source

Continuous glucose monitoring sensors: Past, present and future algorithmic challenges [PDF]

, 2016
Continuous glucose monitoring (CGM) sensors are portable devices that allow measuring and visualizing the glucose concentration in real time almost continuously for several days and are provided with hypo/hyperglycemic alerts and glucose trend ...
Facchinetti, Andrea
core   +2 more sources

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source