Results 11 to 20 of about 98,414 (282)

A systematic review of cardiac in-silico clinical trials. [PDF]

Prog Biomed Eng (Bristol), 2023
Abstract Computational models of the heart are now being used to assess the effectiveness and feasibility of interventions through in-silico clinical trials (ISCTs). As the adoption and acceptance of ISCTs increases, best practices for reporting the methodology and analysing the results will emerge. Focusing in the area of cardiology, we
Rodero C, Baptiste TMG, Barrows RK, Keramati H, Sillett CP, Strocchi M, Lamata P, Niederer SA.   +7 more
europepmc   +5 more sources

In silico Clinical Trials: A New Dawn in Biomedical Research?

Humana.Mente: Journal of Philosophical Studies, 2016
Nowadays, scientific knowledge seems to be increasingly generated using technological methods, but also governed by technological demands and conducted by new technical ways of learning. In this paper I will analyze an effective example of this new trend
Ilaria Malagrinò
doaj   +2 more sources

In Silico Clinical-Trials: Advancing Validation for Regulatory Approval

Current Directions in Biomedical Engineering
The assesment of the safety and efficacy of medical devices can be time-consuming, expensive, and raise ethical concerns. Additionally, the high costs of innovation and lengthy development times may result in increased prices and unequal access for ...
Leuchter Matthias, Supp Laura, Oldenburg Jan, Stiehm Michael, Schmitz Klaus-Peter, Borowski Finja   +5 more
doaj   +2 more sources

In silico clinical trials for pediatric orphan diseases. [PDF]

Sci Rep, 2018
AbstractTo date poor treatment options are available for patients with congenital pseudarthrosis of the tibia (CPT), a pediatric orphan disease. In this study we have performed anin silicoclinical trial on 200 virtual subjects, generated from a previously established model of murine bone regeneration, to tackle the challenges associated with the small,
Carlier A, Vasilevich A, Marechal M, de Boer J, Geris L.   +4 more
europepmc   +4 more sources

In silico clinical trials for anti-aging therapies. [PDF]

Aging (Albany NY), 2019
Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary restriction mimetics), suppression of cellular senescence (senolytics), and cellular reprogramming, which likely have common characteristics and mechanisms of action.
Menendez JA, Cuyàs E, Folguera-Blasco N, Verdura S, Martin-Castillo B, Joven J, Alarcón T.   +6 more
europepmc   +7 more sources

In Silico Clinical Trials in Drug Development: A Systematic Review. [PDF]

Ther Innov Regul Sci
Abstract In the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of the role of so-called in silico clinical trials (ISCTs) in medical applications ...
Chen B, Schneider LC, Röver C, Comets E, Elze MC, Hooker A, IntHout J, Jannot AS, Julkowska D, Mimouni Y, Savelieva M, Stallard N, Ursino M, Vandemeulebroecke M, Weber S, Posch M, Zohar S, Friede T.   +17 more
europepmc   +8 more sources

Artificial Intelligence for In Silico Clinical Trials: A Review

CoRR, 2022
A clinical trial is an essential step in drug development, which is often costly and time-consuming. In silico trials are clinical trials conducted digitally through simulation and modeling as an alternative to traditional clinical trials. AI-enabled in silico trials can increase the case group size by creating virtual cohorts as controls. In addition,
Zifeng Wang 0008, Chufan Gao, Lucas M. Glass, Jimeng Sun 0001   +3 more
openaire   +2 more sources

Ayurvedic formulations: Potential COVID-19 therapeutics?

Phytomedicine Plus, 2022
Background: While Molnupiravir and Paxlovid have recently been approved for use in some countries, there are no widely available treatments for COVID-19, the disease caused by SARS-CoV-2 infection.
Anees Ahmed Mahaboob Ali, Andrea Bugarcic, Nenad Naumovski, Reena Ghildyal   +3 more
doaj   +1 more source

In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Trials, 2021
Imaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability.
Aldo Badano
doaj   +1 more source

Use of Artificial Intelligence to Identify New Mechanisms and Approaches to Therapy of Bone Disorders Associated With Chronic Kidney Disease

Frontiers in Medicine, 2022
Chronic kidney disease (CKD) leads to clinically severe bone loss, resulting from the deranged mineral metabolism that accompanies CKD. Each individual patient presents a unique combination of risk factors, pathologies, and complications of bone disease.
Adam E. Gaweda, Eleanor D. Lederer, Eleanor D. Lederer, Eleanor D. Lederer, Michael E. Brier, Michael E. Brier   +5 more
doaj   +1 more source