Results 61 to 70 of about 98,414 (282)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients [PDF]

, 2016
Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in
Crea, F., Danesi, R., De Gregorio, V., Falcone, A., Fornaro, L., Graziano, F., Loupakis, F., Masi, G., Paolicchi, E., Ricci, V., Ronzoni, M., Vivaldi, C.   +11 more
core   +1 more source

Systems approaches and algorithms for discovery of combinatorial therapies

, 2009
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks.
Agoston V, Balamurugan D, Calzolari D, Carlson JM, Greco WR, Johannesson GH, Nelander S, Segota E, Spall JC, Wadman M, Weinberg RA, Yang K   +11 more
core   +1 more source

NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]

, 2018
Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana, Besharat, ZEIN MERSINI, Capalbo, Carlo, Checquolo, Saula, D'Amati, Giulia, Del Gaudio, Francesca, Diluvio, Giulia, Franciosa, Giulia, Giuli, MARIA VALERIA, Giuliani, Eugenia, Maroder, Marella, Palermo, Rocco, Pignataro, MARIA GEMMA, Talora, Claudio, Vacca, Alessandra   +14 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nanoinformatics: developing new computing applications for nanomedicine [PDF]

, 2012
Nanoinformatics has recently emerged to address the need of computing applications at the nano level. In this regard, the authors have participated in various initiatives to identify its concepts, foundations and challenges.
Alberto Anguita, Alejandro Pazos, Antoine Geissbuhler, B Smith, BY Kim, C Kulikowski, C Rosse, CA Kulikowski, Casimir Kulikowski, Cristian Munteanu, D Dela Iglesia, David Perez-Rey, DG Thomas, Diana De la Iglesia, ED Green, F Martin-Sanchez, Fernando Gonzalez-Nilo, Fernando Martin-Sanchez, Ferran Sanz, George Potamias, Guillermo De la Calle, Guillermo Lopez-Campos, H Berman, IS Kohane, Isabel Hermosilla, Jose Crespo, Jose Maria Barreiro, Josipa Kern, Joyce A. Mitchell, Julio C. Facelli, K Jain, Luciano Milanesi, M Gerstein, M Viceconti, Martin Fritts, Miguel Garcia-Remesal, N Gordon, NA Baker, Nathan Baker, Norbert Graf, P Kiberstis, Paula Otero, Peter Ghazal, Pierre Grangeat, Rada Hussein, Raul E. Cachau, RB Altman, S Bewick, Sabine Koch, SI O’Donoghue, Sonia E. Benitez, V Maojo, V Maojo, V Maojo, V Maojo, Vassilis Moustakis, Victor Maojo, Victoria Lopez-Alonso, Yannick Legre   +58 more
core   +7 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Experimental and theoretical assessment of salvianolic acid B, ellagic acid, and phorbol esters as drug candidates against breast and prostate cancer

Discover Chemistry
Global efforts to develop innovative anti-cancer lead compounds from natural compounds found in plants have gained advanced momentum, focusing on achieving Sustainable Development Goal (SDG) number 3 on good health and well-being.
Russell B. O. Ouma, Usama Raza, Silas M. Ngari, Joshua K. Kibet, Uzair Nisar, Muhammad Waqar Ali   +5 more
doaj   +1 more source

Critical Appraisal and Future Challenges of Artificial Intelligence and Anticancer Drug Development

Pharmaceuticals
The conventional rules for anti-cancer drug development are no longer sufficient given the relatively limited number of patients available for therapeutic trials. It is thus a real challenge to better design trials in the context of new drug approval for
Emmanuel Chamorey, Jocelyn Gal, Baharia Mograbi, Gérard Milano   +3 more
doaj   +1 more source

In Silico Evaluation of Pharmacokinetic Optimization for Antimitogram-Based Clinical Trials [PDF]

Cancer Research, 2018
Abstract Antimitograms are prototype in vitro tests for evaluating chemotherapeutic efficacy using patient-derived primary cancer cells. These tests might help optimize treatment from a pharmacodynamic standpoint by guiding treatment selection. However, they are technically challenging and require refinements and trials to demonstrate
Skerdi, Haviari, Benoît, You, Michel, Tod   +2 more
openaire   +2 more sources