Results 71 to 80 of about 98,414 (282)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Predicting Blood Glucose with an LSTM and Bi-LSTM Based Deep Neural Network

, 2018
A deep learning network was used to predict future blood glucose levels, as this can permit diabetes patients to take action before imminent hyperglycaemia and hypoglycaemia.
Bally, Lia, Jankovic, Marko V., Mougiakakou, Stavroula G., Sun, Qingnan   +3 more
core   +1 more source

COST EFFECTIVNESS ANALYSIS OF REAL AND IN-SILICO CLINICAL TRIALS FOR STENT DEPLOYMENT

1st Serbian International Conference on Applied Artificial Intelligence (SICAAI), 2022
The global coronary and peripheral stent market size was valued at USD 5.91 billion in 2019 and is projected to reach USD 8.08 billion by 2027 and the new and innovative devices are invented and developed rapidly. In this process of developing new models of stents, one of the key phases is clinical testing on live patients.
Gacic, Marija, Kaplarevic, Milica, Filipovic, Nenad   +2 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Improving the reliability of model-based decision-making estimates in the two-stage decision task with reaction-times and drift-diffusion modeling [PDF]

, 2019
A well-established notion in cognitive neuroscience proposes that multiple brain systems contribute to choice behaviour. These include: (1) a model-free system that uses values cached from the outcome history of alternative actions, and (2) a model-based
Dolan, RJ, Hauser, TU, Keramati, M, Moran, R, Moutoussis, M, NSPN consortium,, Shahar, N   +6 more
core   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows [PDF]

, 2017
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot
A Goncearenco, A Goncearenco, A Marchler-Bauer, A Truszkowski, AA Bogan, B Graves, B Ma, BA Shoemaker, BA Shoemaker, BA Shoemaker, BJ Smith, CA Goble, CM Yates, D Petrey, E Cukuroglu, FP Davis, H Perez-Sanchez, HS Haase, J Bhagat, J Cinatl, JA Wells, K Wolstencroft, M Guharoy, M Li, M Li, M Li, M Petukh, M Tyagi, MK Gilson, MP Mazanetz, N Estrada-Ortiz, P Aloy, P Aloy, P Filippakopoulos, R Mosca, RR Thangudu, S Beisken, S Kim, S Shangary, S Teng, T Rolland, W Yang, WS Valdar, Y Wang, Y Zhao   +44 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome [PDF]

, 2017
Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly ...
A Das, A Das, A Das, A Protti, Anup Das, AS Slutsky, B Ma, CB Massa, Declan G. Bates, DR Riva, E Fan, F Jardin, F Jardin, G Musch, GF De Matos, H Jellinek, HE Fessler, HH Webb, J Hardman, J Tuchschmidt, J Villar, JB Borges, JG Hardman, Jonathan G. Hardman, JW Biondi, KG Hickling, L Engelmann, L Gattinoni, L Gattinoni, L Gattinoni, LL Liu, M Briel, M Ursino, MA Hayes, Mainul Haque, Marc Chikhani, MB Amato, MJ McNamara, MR Pinsky, Oana Cole, P Caironi, R Pearse, RM Leach, S Crotti, S Grasso, SC Lim, SE Lapinsky, SM Scharf, T De Campos, T Luecke, W Wang, WC Shoemaker, WC Shoemaker, Wenfei Wang   +53 more
core   +5 more sources

In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials [PDF]

Experimental Biology and Medicine, 2017
Current strategies to delineate the risk of serious drug-induced liver injury associated with drugs rely on assessment of serum biomarkers that have been utilized for many decades. In particular, serum alanine aminotransferase and total bilirubin levels are typically used to assess hepatic integrity and function, respectively.
Watkins, Paul B, Church, Rachel J
openaire   +2 more sources