Results 131 to 140 of about 98,414 (282)

A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke. [PDF]

Interface Focus, 2021
Józsa TI, Padmos RM, Samuels N, El-Bouri WK, Hoekstra AG, Payne SJ.   +5 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Bayesian Inference-Based Gaussian Mixture Models With Optimal Components Estimation Towards Large-Scale Synthetic Data Generation for In Silico Clinical Trials. [PDF]

IEEE Open J Eng Med Biol, 2022
Pezoulas VC, Tachos NS, Gkois G, Olivotto I, Barlocco F, Fotiadis DI.   +5 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A Novel Approach to Generate a Virtual Population of Human Coronary Arteries for In Silico Clinical Trials of Stent Design. [PDF]

IEEE Open J Eng Med Biol, 2021
Pleouras D, Sakellarios A, Rigas G, Karanasiou GS, Tsompou P, Karanasiou G, Kigka V, Kyriakidis S, Pezoulas V, Gois G, Tachos N, Ramos A, Pelosi G, Rocchiccioli S, Michalis L, Fotiadis DI.   +15 more
europepmc   +1 more source

In Silico Clinical Trials - Review

International Journal of Science and Research (IJSR), 2023
openaire   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

In silico prediction of optimal multifactorial intervention in chronic kidney disease

Journal of Translational Medicine
Background Chronic kidney disease (CKD) contributes to global morbidity and mortality. Early, targeted intervention can help mitigate its impact. CK273 is a urinary peptide classifier previously validated in a prospective clinical trial for the early ...
Agnieszka Latosinska, Ioanna K. Mina, Thi Minh Nghia Nguyen, Igor Golovko, Felix Keller, Gert Mayer, Peter Rossing, Jan A. Staessen, Christian Delles, Joachim Beige, Griet Glorieux, Andrew L. Clark, Joost P. Schanstra, Antonia Vlahou, Karlheinz Peter, Ivan Rychlík, Alberto Ortiz, Archie Campbell, Harald Rupprecht, Frederik Persson, Harald Mischak, Justyna Siwy   +21 more
doaj   +1 more source

Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer

Frontiers in Systems Biology
Insilico clinical trials that simulate individualized mechanisms of action offer a powerful approach to assess drug efficacy across large and diverse patient populations, while also enabling the identification of predictive biomarkers.
Juan Manuel García-Illarramendi, Juan Manuel García-Illarramendi, Pedro Matos-Filipe, Pedro Matos-Filipe, Jose Manuel Mas, Judith Farrés, Xavier Daura, Xavier Daura, Xavier Daura   +8 more
doaj   +1 more source