Results 231 to 240 of about 98,414 (282)

When Selectivity Increases Uncertainty: Context-Dependent Pharmacology in Antibody Drug Development. [PDF]

Clin Transl Sci
Liao X, Cao Y.
europepmc   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal, Uwe Aickelin, Ellen Otte   +2 more
wiley   +1 more source

Opportunities and barriers for innovation at the interface of engineering and maternal-fetal medicine. [PDF]

Commun Eng
Howlett TS, Parchem JG, Swingle KL.
europepmc   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Breaking Lock-ins to Enable a Green Pharmacy. [PDF]

Environ Sci Technol
Shalin A, Diamond ML, Wang Z.
europepmc   +1 more source

In silico Drug Discovery: Bridging the Gaps in Preclinical Translation. [PDF]

Drug Discov Today
Markossian S, Baskir HM, Grossman AC, Chandran S, Rele S, Hall MD, Amaro RE, Tropsha A, Zakharov AV.   +8 more
europepmc   +1 more source

Androgen Receptor Point Mutations: A Mechanism of Therapeutic Resistance and a Framework for Rational Drug Design. [PDF]

Cancers (Basel)
Colah A, Ferková S, Zhang H, Liu G, MacGillivray L, Boudreault PL, Ricke W.   +6 more
europepmc   +1 more source

Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells. [PDF]

Front Immunol
Fazeli A, Ullrich E, Cathomen T, Bexte T.   +3 more
europepmc   +1 more source