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In silico environments augment clinical trials
IEEE Engineering in Medicine and Biology Magazine, 1996One of the most promising new approaches to interpreting complex systems data is to generate self-organizing simulations. We have previously applied Markov random field methods to create virtual worlds for the prototyping of wetlab experimentation.
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Integrating machine learning into the in silico clinical trial pipeline
Mathematical BiosciencesIn silico clinical trials offer a powerful tool for overcoming several limitations of traditional clinical trials. Conventional trials are time- and resource-intensive, typically designed to assess average effects across a population while being restricted to studying the impact of a fixed treatment protocol.
Rebecca A. Bekker +4 more
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Development of Synthetic Patient Populations and In Silico Clinical Trials
2018Drug development, which includes clinical trials, is a lengthy and expensive process that could significantly benefit from predictive modeling and in silico testing. Additionally, current treatments were designed based on the average patient using the “one size fits all” protocol.
Ramin Zand, Vida Abedi, Pinyi Lu
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In Silico Clinical Trials: A Possible Response to Complexity in Pharmacology
2020The complex nature of human diseases, the significant differences between individuals, their own specificity and the inevitable variability in how a treatment is administered make pharmacological research extremely difficult. Due to the inability to completely predict how a product will affect individual patients, it’s not unusual for a drug to show ...
Boem Federico +2 more
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Technical Note: In silico imaging tools from the VICTRE clinical trial
Medical Physics, 2019PurposeIn silico imaging clinical trials are emerging alternative sources of evidence for regulatory evaluation and are typically cheaper and faster than human trials. In this Note, we describe the set of in silico imaging software tools used in the VICTRE (Virtual Clinical Trial for Regulatory Evaluation) which replicated a traditional trial using a ...
Diksha, Sharma +7 more
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Mathematics in culture and clinic: from understanding cell behaviours to in silico clinical trials
2023The use of mechanistic models can provide insight at every point in the understanding of disease and treatment, from traditional bench experiments through to emerging clinical applications, such as *in silico* clinical trials (ISTs). This talk will cover two distinct areas of research that sit at opposite ends of this spectrum. Firstly, in the clinical
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Cost-effectiveness analysis of in silico clinical trials of vascular stents
2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE), 2021Marija Gacic +2 more
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In silico thrombectomy trials for acute ischemic stroke
Computer Methods and Programs in Biomedicine, 2023Claire Miller +2 more
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Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices
IEEE Journal of Biomedical and Health Informatics, 2022Francesco Pappalardo +2 more
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