Results 271 to 280 of about 170,756 (308)
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In silico design of tubulin-targeted antimitotic peptides
Nature Chemistry, 2009Microtubules are polymeric structures formed by the self-assembly of tubulin dimers. The growth and shrinkage of these dynamic arrays have a key role during the cell-proliferation process. This makes tubulin the molecular target of many anticancer drugs currently in use or under clinical trial.
S. Pieraccini +7 more
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In silico Methods for Drug Design
Current Topics in Medicinal Chemistry, 2023Omar, Deeb, Jia, Zhou
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In Silico Methods for Drug Design and Discovery
2020Computer-aided drug design (CADD) methodologies are playing an ever-increasing role in drug discovery that are critical in the cost-effective identification of promising drug candidates. These computational methods are relevant in limiting the use of animal models in pharmacological research, for aiding the rational design of novel and safe drug ...
Simone Brogi +4 more
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Structure‐Based and in silico Design of Hsp90 Inhibitors
ChemMedChem, 2009AbstractThe molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure‐based design of small molecules aimed at inhibiting the chaperone activity of ...
M. Sgobba, RASTELLI, Giulio
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2006
In the last 10 yr, efforts have begun to combine the goals and approaches of computational molecular design and protein sequence analysis to provide tools for the rational mutagenesis and functional modification of proteins. These approaches use analysis of the three-dimensional structure of a protein to guide the selection of appropriate amino acid ...
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In the last 10 yr, efforts have begun to combine the goals and approaches of computational molecular design and protein sequence analysis to provide tools for the rational mutagenesis and functional modification of proteins. These approaches use analysis of the three-dimensional structure of a protein to guide the selection of appropriate amino acid ...
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Databases and In Silico Tools for Vaccine Design
2013In vaccine design, databases and in silico tools play different but complementary roles. Databases collect experimentally verified vaccines and vaccine components, and in silico tools provide computational methods to predict and design new vaccines and vaccine components.
Yongqun, He, Zuoshuang, Xiang
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In silico approaches to RNA aptamer design
Biochimie, 2018RNA aptamers are ribonucleic acids that bind to specific target molecules. An RNA aptamer for a disease-related protein has great potential for development into a new drug. However, huge time and cost investments are required to develop an RNA aptamer into a pharmaceutical.
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Protocols for the In Silico Design of RNA Nanostructures
2008Recent developments in the field of nanobiology have significantly expanded the possibilities for new modalities in the treatment of many diseases, including cancer. Ribonucleic acid (RNA) represents a relatively new molecular material for the development of these biologically oriented nanodevices. In addition, RNA nanobiology presents a relatively new
Bruce A, Shapiro +3 more
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Complex In Silico RNA Design with MoiRNAiFold
In the advent of the RNA therapeutics and diagnostics era, it is of great relevance to introduce new and more efficient RNA technologies that prove to be effective tools in practical contexts. Moreover, it is of utmost importance to develop and provide access to computational tools capable of designing such RNA constructs.Cristina, Alsina, Ivan, Dotu
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Drug Design for XRCC4 in Silico
2009 2nd International Conference on Biomedical Engineering and Informatics, 2009Hung-Jin Huang +9 more
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