Results 251 to 260 of about 170,756 (308)

In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects. [PDF]

Lasers Med Sci
Nishimura T, Watanabe Y, Shimojo Y, Ozawa T, Tsuruta D.   +4 more
europepmc   +1 more source

In Silico Design, Optimization, and Evaluation of a Multi-Epitope Vaccine Targeting the <i>Clostridium perfringens</i> Collagen Adhesin Protein. [PDF]

Microorganisms
Chundru D, Bhattrai S, Timilsina M, Lillehoj H, Sun Z, Ghanem M, Li C.   +6 more
europepmc   +1 more source

In Silico Design and Characterization of a Multiepitope Vaccine Candidate Against <i>Brucella canis</i> Using a Reverse Vaccinology Approach. [PDF]

J Immunol Res
Arriagada V, Osorio A, Carrera-Naipil C, Villacis-Aguirre CA, Escobar C, Morales N, Villa D, Mardones L, Pérez D, Jara M, Molina RE, Ferrari Í, Azocar S, Gómez LA, Oñate ÁA.   +14 more
europepmc   +1 more source

In silico design of new proteins

, 2013
Correa Marrero, Miguel, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
openaire   +1 more source

In Silico Design of Antimicrobial Peptides

, 2014
The rapid spread of drug-resistant pathogenic microbial strains has created an urgent need for the development of new anti-infective molecules, having different mechanism of action in comparison to existing drugs. Natural antimicrobial peptides (AMPs) represent a novel class of molecules with a broad spectrum of activity and a low rate in inducing ...
Maccari Giuseppe, Di Luca Mariagrazia, Nifosi Riccardo   +2 more
openaire   +5 more sources

In silico design of foldable lasso peptides [PDF]

Biophysical Journal
Lasso peptides are a unique class of natural products with distinctively threaded structures, conferring exceptional stability against thermal and proteolytic degradation. Despite their promising biotechnological and pharmaceutical applications, reported attempts to prepare them by chemical synthesis result in forming the nonthreaded branched-cyclic ...
John D.M. Nguyen, Gabriel C.A. da Hora, Marcus C. Mifflin, Andrew G. Roberts, Jessica M.J. Swanson   +4 more
openaire   +3 more sources

Methods and Applications of In Silico Aptamer Design and Modeling

International Journal of Molecular Sciences, 2020
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow the design of in vitro aptamers that bind particularly to a target
Andrey A Buglak, Alexey V Samokhvalov, Anatoly V Zherdev   +2 more
exaly   +2 more sources

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Fragment-to-lead tailored in silico design

Drug Discovery Today: Technologies, 2021
Fragment-based drug discovery (FBDD) emerged as a disruptive technology and became established during the last two decades. Its rationality and low entry costs make it appealing, and the numerous examples of approved drugs discovered through FBDD validate the approach. However, FBDD still faces numerous challenges. Perhaps the most important one is the
Moira Rachman, Serena Piticchio, Maciej Majewski, Xavier Barril   +3 more
openaire   +2 more sources

In Silico Design of Anticancer Peptides

2017
In the past few years, small peptides having anticancer properties have emerged as a potential avenue for cancer therapy. Compared to current anti-cancer chemotherapeutic drugs (or small molecules), anticancer peptides (ACPs) have numerous advantageous properties, such as high specificity, low production cost, high tumor penetration, ease of synthesis ...
Shailesh, Kumar, Hui, Li
openaire   +2 more sources