Results 261 to 270 of about 115,710,970 (297)
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2006
In the last 10 yr, efforts have begun to combine the goals and approaches of computational molecular design and protein sequence analysis to provide tools for the rational mutagenesis and functional modification of proteins. These approaches use analysis of the three-dimensional structure of a protein to guide the selection of appropriate amino acid ...
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In the last 10 yr, efforts have begun to combine the goals and approaches of computational molecular design and protein sequence analysis to provide tools for the rational mutagenesis and functional modification of proteins. These approaches use analysis of the three-dimensional structure of a protein to guide the selection of appropriate amino acid ...
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In silico design of tubulin-targeted antimitotic peptides
Nature Chemistry, 2009Microtubules are polymeric structures formed by the self-assembly of tubulin dimers. The growth and shrinkage of these dynamic arrays have a key role during the cell-proliferation process. This makes tubulin the molecular target of many anticancer drugs currently in use or under clinical trial.
S. Pieraccini +7 more
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In silico Methods for Drug Design
Current Topics in Medicinal Chemistry, 2023Omar, Deeb, Jia, Zhou
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In silico approaches to RNA aptamer design
Biochimie, 2018RNA aptamers are ribonucleic acids that bind to specific target molecules. An RNA aptamer for a disease-related protein has great potential for development into a new drug. However, huge time and cost investments are required to develop an RNA aptamer into a pharmaceutical.
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In Silico PCR Primer Designing and Validation
2015Polymerase chain reaction (PCR) is an enzymatic reaction whose efficiency and sensitivity largely depend on the efficiency of the primers that are used for the amplification of a concerned gene/DNA fragment. Selective amplification of nucleic acid molecules initially present in minute quantities provides a powerful tool for analyzing nucleic acids.
Anil, Kumar, Nikita, Chordia
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Structure‐Based and in silico Design of Hsp90 Inhibitors
ChemMedChem, 2009AbstractThe molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure‐based design of small molecules aimed at inhibiting the chaperone activity of ...
M. Sgobba, RASTELLI, Giulio
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Databases and In Silico Tools for Vaccine Design
2013In vaccine design, databases and in silico tools play different but complementary roles. Databases collect experimentally verified vaccines and vaccine components, and in silico tools provide computational methods to predict and design new vaccines and vaccine components.
Yongqun, He, Zuoshuang, Xiang
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Protocols for the In Silico Design of RNA Nanostructures
2008Recent developments in the field of nanobiology have significantly expanded the possibilities for new modalities in the treatment of many diseases, including cancer. Ribonucleic acid (RNA) represents a relatively new molecular material for the development of these biologically oriented nanodevices. In addition, RNA nanobiology presents a relatively new
Bruce A, Shapiro +3 more
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Complex In Silico RNA Design with MoiRNAiFold
In the advent of the RNA therapeutics and diagnostics era, it is of great relevance to introduce new and more efficient RNA technologies that prove to be effective tools in practical contexts. Moreover, it is of utmost importance to develop and provide access to computational tools capable of designing such RNA constructs.Cristina, Alsina, Ivan, Dotu
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In Silico Design of Functional DNA Constructs
2012The promise of synthetic biology lies in the creation of novel function from the proper combination of genetic elements. De novo gene synthesis has become a cost-effective method for building virtually any conceptualized genetic construct, removing the constraints of extant sequences, and greatly facilitating study of the relationships between gene ...
Alan, Villalobos +2 more
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