Results 71 to 80 of about 165,849 (202)

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources

In silico Models of Alcohol Dependence and Treatment [PDF]

Frontiers in Psychiatry, 2012
In this paper we view alcohol dependence and the response to treatment as a recurrent bio-behavioral process developing in time and propose formal models of this process combining behavior and biology in silico. The behavioral components of alcohol dependence and treatment are formally described by a stochastic process of human behavior, which serves ...
Kovatchev, Boris, Breton, Marc, Johnson, Bankole   +2 more
openaire   +3 more sources

Use of Computational Modeling to Study Joint Degeneration: A Review

Frontiers in Bioengineering and Biotechnology, 2020
Osteoarthritis (OA), a degenerative joint disease, is the most common chronic condition of the joints, which cannot be prevented effectively. Computational modeling of joint degradation allows to estimate the patient-specific progression of OA, which can
Satanik Mukherjee, Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris, Liesbet Geris, Liesbet Geris   +6 more
doaj   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

In Silico 3D Modeling of Binding Activities

, 2016
In silico three-dimensional (3D) molecular modeling tools based upon the receptor/enzyme-ligand docking simulation in protein crystal structures and/or homology modeling of receptors have been reliably used in pharmacological research and development for decades.
MORO, STEFANO, STURLESE, MATTIA, CIANCETTA, ANTONELLA, Floris, Matteo   +3 more
openaire   +4 more sources

In Silico Models for Ecotoxicity of Pharmaceuticals [PDF]

, 2016
Pharmaceuticals and their active metabolites are one of the significantly emerging environmental toxicants. The major routes of entry of pharmaceuticals into the environment are industries, hospitals, or direct disposal of unwanted or expired drugs made by the patient.
Roy, Kunal, Kar, Supratik
openaire   +2 more sources

Physicochemical Exploration and Computational Analysis of Bone After Subchronic Exposure to Kalach 360 SL in Female Wistar Rats

Toxics
Glyphosate (N-phosphonomethylglycine) is a widely used organophosphorus herbicide that inhibits the shikimate pathway, a crucial metabolic route responsible for the synthesis of aromatic amino acids in plants and certain microorganisms.
Latifa Hamdaoui, Hafedh El Feki, Marwa Ben Amor, Hassane Oudadesse, Riadh Badraoui, Naila Khalil, Faten Brahmi, Saoussen Jilani, Bandar Aloufi, Ibtissem Ben Amara, Tarek Rebai   +10 more
doaj   +1 more source

Hepatitis E Virus Cysteine Protease Has Papain Like Properties Validated by in silico Modeling and Cell-Free Inhibition Assays

Frontiers in Cellular and Infection Microbiology, 2020
Hepatitis E virus (HEV) has emerged as a global health concern during the last decade. In spite of a high mortality rate in pregnant women with fulminant hepatitis, no antiviral drugs or licensed vaccine is available in India.
Shweta Saraswat, Meenakshi Chaudhary, Deepak Sehgal   +2 more
doaj   +1 more source

Edge usage, motifs and regulatory logic for cell cycling genetic networks

, 2013
The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A., Martin, O. C., Zagorski, M.   +2 more
core   +3 more sources

Editorial: Non-linear analysis and machine learning in cardiology

Frontiers in Physiology, 2023
Hans Dierckx, Hans Dierckx, Xiaopeng Zhao, Elena G. Tolkacheva, Elena G. Tolkacheva, Elena G. Tolkacheva   +5 more
doaj   +1 more source