Results 71 to 80 of about 236,648 (327)

Methods and Applications of In Silico Aptamer Design and Modeling

International Journal of Molecular Sciences, 2020
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow the design of in vitro aptamers that bind particularly to a target
A. A. Buglak, A. Samokhvalov, A. Zherdev, B. Dzantiev   +3 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Characterization and optimization of azo dyes degrading microbes isolated from textile effluent

Scientific Reports
Azo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks.
Arshiya Khan, Anuraj Nayarisseri, Sanjeev Kumar Singh   +2 more
doaj   +1 more source

Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus

Anais da Academia Brasileira de Ciências, 2021
Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects.
PEDRO HENRIQUE SETTE-DE-SOUZA, MOAN J.F. COSTA, FÁBIO A.C. ARAÚJO, EVERTON N. ALENCAR, LUCAS AMARAL-MACHADO   +4 more
doaj   +1 more source

In silico modelling of hormone response elements [PDF]

BMC Bioinformatics, 2006
Abstract Background An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for ...
Stepanova, Maria, Lin, Feng, Lin, Valerie   +2 more
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. [PDF]

, 2009
BackgroundA growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed.
Jamshidi, Neema, Palsson, Bernhard O
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimizing human pulmonary perfusion measurement using an in silico model of arterial spin labeling magnetic resonance imaging. [PDF]

, 2019
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is an imaging methodology that uses blood as an endogenous contrast agent to quantify flow.
Addo, Daniel A, Burrowes, Kelly Suzzane, Kang, Wendy, Prisk, Gordon Kim, Tawhai, Merryn H   +4 more
core   +1 more source

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]

, 2016
Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei, Bown, James L., Goltsov, Alexey, Harrison, David J., Mullen, Peter, Robertson, Paul, Shovman, Mark   +6 more
core   +3 more sources