Results 61 to 70 of about 114,431,160 (255)
, 2020 Fatty acid esters of hydroxy fatty acids (FAHFAs) are a family of recently discovered lipids with important physiological functions in mammals and plants.
Yu-Qi Feng +13 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
DataSheet1_Structural Equation Modeling of In silico Perturbations.pdf
, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in ...
Kevin Day (4735620) +7 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
On the emergence and evolution of artificial cell signaling networks [PDF]
, 2007 This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
core +3 more sources
Journal of Orthopaedic TranslationEstablish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models.
Qi Gao +7 more
doaj +1 more source
Functional complexity of the Leishmania granuloma and the potential of in silico modelling
Frontiers in Immunology, 2013 In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development.
John eMoore +7 more
doaj +1 more source
Journal of Genetic Engineering and Biotechnology, 2020 Background Pharmaceutically important curcuminoid synthesis in C. longa is controlled by CURS1, CURS2, and CURS3 genes. The present study detected the physicochemical properties and structural characteristics including the secondary and 3D structure of ...
R. Santhoshkumar, A. Yusuf
doaj +1 more source
Table2_Structural Equation Modeling of In silico Perturbations.XLSX
, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in ...
Kevin Day (4735620) +7 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source