Results 41 to 50 of about 114,431,160 (255)

Mathematical modeling of tumor growth and treatment [PDF]

, 2014
Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research.
Chaplain, Mark A. J., Enderling, Heiko
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Characterization and optimization of azo dyes degrading microbes isolated from textile effluent

Scientific Reports
Azo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks.
Arshiya Khan, Anuraj Nayarisseri, Sanjeev Kumar Singh   +2 more
doaj   +1 more source

Arrhythmia models: in vivo, in vitro and in silico [PDF]

Drug Discovery Today: Disease Models, 2009
Remodeling of ion channel and/or intracellular calcium handling properties lies at the heart of numerous congenital and acquired cardiovascular disorders that culminate in lethal arrhythmias. Typically pathophysiological remodeling is caused by a complex interplay between electrical, mechanical, structural, metabolic, and genetic alterations which ...
Fadi G, Akar, Colleen E, Clancy
openaire   +2 more sources

in-silico-NOTES

, 2014
NOTES describing the pipeline steps used to analyze the in silico ...
Brant C. Faircloth (143432), Michael G. Branstetter (609954), Noor D. White (3248478), Séan G. Brady (3248475)   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An in silico study of bioactive compounds of Annona muricata in the design of ani-prostate cancer agent: MM/GBSA, pharmacophore modeling and ADMET parameters

Informatics in Medicine Unlocked, 2023
One of the most frequent diseases that affect and kill men globally is prostate cancer. Treatment for prostate cancer has become unpleasant and upsetting for individuals due to the resulting resistance, toxicity, and adverse effects of standard ...
Victor Onukwube Apeh, Abayomi Emmanuel Adegboyega, Ifeoma Felicia Chukwuma, Chinenye Jane Ugwah-Oguejiofor, Patrick Maduabuchi Aja, Josephine Omose Ofeimun, Boniface Anthony Ale, Grace Inioluwa Johnson, Lilian Nwanneka Ebenyi, Opeyemi Iwaloye, Stephen Adakole Ejembi, Flora Nnenna Ezugworie, Titilayo Omolara Johnson   +12 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus

Anais da Academia Brasileira de Ciências, 2021
Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects.
PEDRO HENRIQUE SETTE-DE-SOUZA, MOAN J.F. COSTA, FÁBIO A.C. ARAÚJO, EVERTON N. ALENCAR, LUCAS AMARAL-MACHADO   +4 more
doaj   +1 more source

Modeling ChIP Sequencing In Silico with Applications

PLoS Computational Biology, 2008
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled.
Zhengdong D. Zhang, Joel S. Rozowsky, Michael Snyder 0001, Joseph T. Chang, Mark Gerstein   +4 more
openaire   +3 more sources