Results 51 to 60 of about 93,106 (305)

An in silico study of bioactive compounds of Annona muricata in the design of ani-prostate cancer agent: MM/GBSA, pharmacophore modeling and ADMET parameters

Informatics in Medicine Unlocked, 2023
One of the most frequent diseases that affect and kill men globally is prostate cancer. Treatment for prostate cancer has become unpleasant and upsetting for individuals due to the resulting resistance, toxicity, and adverse effects of standard ...
Victor Onukwube Apeh, Abayomi Emmanuel Adegboyega, Ifeoma Felicia Chukwuma, Chinenye Jane Ugwah-Oguejiofor, Patrick Maduabuchi Aja, Josephine Omose Ofeimun, Boniface Anthony Ale, Grace Inioluwa Johnson, Lilian Nwanneka Ebenyi, Opeyemi Iwaloye, Stephen Adakole Ejembi, Flora Nnenna Ezugworie, Titilayo Omolara Johnson   +12 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mathematical modeling of tumor growth and treatment

, 2014
Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research.
Chaplain, Mark A. J., Enderling, Heiko
core   +1 more source

Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus

Anais da Academia Brasileira de Ciências, 2021
Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects.
PEDRO HENRIQUE SETTE-DE-SOUZA, MOAN J.F. COSTA, FÁBIO A.C. ARAÚJO, EVERTON N. ALENCAR, LUCAS AMARAL-MACHADO   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Maria E Merlo, Wellington Elizabeth MH, David A Hodgson, Breitling, Rainer, Breitling, R., Hodgson, David A.,, Breitling, Rainer,, Breitling, R, Breitling Rainer, Merlo, Maria E., Wellington, Elizabeth M H, Wellington, EMH, Merlo, Maria E.,, Mohammad T Alam, Eriko Takano, Hodgson, D.A., Takano, Eriko,, Hodgson, David A., Alam, M.T., Takano Eriko, Hodgson, D. A., STREAM Consortium, Alam, Mohammad T.,, Takano, E, Takano, E., Merlo, ME, Rainer Breitling, Hodgson, DA, Wellington, Elizabeth M. H., Wellington, Elizabeth M.H.,, Merlo, M.E., Wellington, E.M.H., Alam, Mohammad T., Alam, MT, Alam Mohammad T, Takano, Eriko, Merlo Maria E, Elizabeth MH Wellington, HASH(0x55a67fd0c960), Hodgson David A, Wellington, E. M. H., Takano, Eriko; id_orcid, Merlo, Maria E.; id_orcid, The STREAM Consortium (stream)   +43 more
core   +1 more source

In silico study of Bacillus spB201 amylase through protein sequence inspection

Journal of the Arab Society for Medical Research
Background/aim Bioinformatics is the automatic processing of biological information, and it is a helpful tool to study the structure-function relationship of various proteins.
Sameh Ben Mabrouk, Bouthaina Ben Hadj Hmida, Ikram Boukthir, Slim Cherif   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Mesoscopic Modeling of Stroke Treatment

, 2023
Strokes are a leading cause of disability and death globally, and effective treatments remain a critical medical challenge. They are classified into two main types: ischemic and hemorrhagic.
Petkantchin, Rémy Valentin
core   +1 more source

Modeling mechanical ventilation in silico—potential and pitfalls [PDF]

, 2022
Computer simulation offers a fresh approach to traditional medical research that is particularly well suited to investigating issues related to mechanical ventilation.
Hannon, David M., Hardman, Jonathan G., Das, Anup, Bates, Declan G., Mistry, Sonal, Saffaran, Sina, Laffey, John G., Brook, Bindi S.   +7 more
core   +1 more source