Results 71 to 80 of about 93,106 (305)
Arrhythmia models: in vivo, in vitro and in silico [PDF]
Drug Discovery Today: Disease Models, 2009 Remodeling of ion channel and/or intracellular calcium handling properties lies at the heart of numerous congenital and acquired cardiovascular disorders that culminate in lethal arrhythmias. Typically pathophysiological remodeling is caused by a complex interplay between electrical, mechanical, structural, metabolic, and genetic alterations which ...
Fadi G, Akar, Colleen E, Clancy
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Doxorubicin PK/PD modeling in multiple myeloma: towards in silico trials
Biology DirectDoxorubicin (DOXO) is a well-known chemotherapy drug, which is widely used in the treatment of Multiple Myeloma (MM), a treatable but not curable type of blood cancer.
Daniele Andrean +4 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Development and evaluation of pid controllers for glucose control in people with type 1 diabetes mellitus [PDF]
, 2012 The aim of this research is to develop and evaluate a novel, model-based PID control design method to achieve normo-glycemia with an artificial pancreas.
Tagliavini, Alessia
core
BMC Bioinformatics, 2019 Background Contemporary biological observations have revealed a large variety of mechanisms acting during the expansion of a tumor. However, there are still many qualitative and quantitative aspects of the phenomenon that remain largely unknown.
Markos Antonopoulos +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
BMC Bioinformatics, 2020 Background In 2018, about 10 million people were found infected by tuberculosis, with approximately 1.2 million deaths worldwide. Despite these numbers have been relatively stable in recent years, tuberculosis is still considered one of the top 10 ...
Giulia Russo +10 more
doaj +1 more source
In silico modelling of hormone response elements [PDF]
BMC Bioinformatics, 2006 Abstract Background An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for ...
Maria Stepanova +2 more
openaire +2 more sources