Results 71 to 80 of about 114,431,160 (255)
in-silico-uce-probes-to-contigs.lastz.tar.gz
, 2014 LASTZ files showing mapping of UCE probes onto in silico genome slices AND probe.matches.sqlite ...
Brant C. Faircloth (143432) +7 more
core +1 more source
In silico modelling of hormone response elements [PDF]
BMC Bioinformatics, 2006 Abstract Background An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for ...
Maria Stepanova +2 more
openaire +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Doxorubicin PK/PD modeling in multiple myeloma: towards in silico trials
Biology DirectDoxorubicin (DOXO) is a well-known chemotherapy drug, which is widely used in the treatment of Multiple Myeloma (MM), a treatable but not curable type of blood cancer.
Daniele Andrean +4 more
doaj +1 more source
in-silico-taxon-set-alignment-data.tar.gz
, 2014 Archive file containing nested directories of in-silico alignment and analysis data.
Brant C. Faircloth (143432) +7 more
core +1 more source
High Accuracy in Silico Sulfotransferase Models [PDF]
Journal of Biological Chemistry, 2013 Predicting enzymatic behavior in silico is an integral part of our efforts to understand biology. Hundreds of millions of compounds lie in targeted in silico libraries waiting for their metabolic potential to be discovered. In silico "enzymes" capable of accurately determining whether compounds can inhibit or react is often the missing piece in this ...
Ian, Cook +3 more
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
BMC Bioinformatics, 2019 Background Contemporary biological observations have revealed a large variety of mechanisms acting during the expansion of a tumor. However, there are still many qualitative and quantitative aspects of the phenomenon that remain largely unknown.
Markos Antonopoulos +3 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
BMC Bioinformatics, 2020 Background In 2018, about 10 million people were found infected by tuberculosis, with approximately 1.2 million deaths worldwide. Despite these numbers have been relatively stable in recent years, tuberculosis is still considered one of the top 10 ...
Giulia Russo +10 more
doaj +1 more source