Results 31 to 40 of about 93,106 (305)
"In silico" prediction of drug transport across physiological barriers [PDF]
, 2011 Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
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In silico Models of Alcohol Dependence and Treatment [PDF]
Frontiers in Psychiatry, 2012 In this paper we view alcohol dependence and the response to treatment as a recurrent bio-behavioral process developing in time and propose formal models of this process combining behavior and biology in silico. The behavioral components of alcohol dependence and treatment are formally described by a stochastic process of human behavior, which serves ...
Kovatchev, Boris +2 more
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Table2_Structural Equation Modeling of In silico Perturbations.XLSX
, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in ...
Kevin Day (4735620) +7 more
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In-silico modeling of granulomatous diseases [PDF]
Current Opinion in Pulmonary Medicine, 2016 The pathogenesis of genetically complex granulomatous diseases, such as sarcoidosis and latent tuberculosis, remains largely unknown. With the recent advent of more powerful research tools, such as genome-wide expression platforms, comes the challenge of making sense of the enormous data sets so generated. This manuscript will provide demonstrations of
openaire +2 more sources
Table1_Structural Equation Modeling of In silico Perturbations.XLSX
, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in ...
Kevin Day (4735620) +7 more
core +1 more source
In-Silico Trials for Treatment of Acute Ischemic Stroke
Frontiers in Neurology, 2020 Despite improved treatment, a large portion of patients with acute ischemic stroke due to a large vessel occlusion have poor functional outcome. Further research exploring novel treatments and better patient selection has therefore been initiated.
Praneeta R. Konduri +7 more
doaj +1 more source
DataSheet1_Structural Equation Modeling of In silico Perturbations.pdf
, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in ...
Kevin Day (4735620) +7 more
core +1 more source
Journal of Genetic Engineering and Biotechnology, 2020 Background Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches.
Afnan Saleem, Shiveeli Rajput
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Building blocks of microphysiological system to model physiology and pathophysiology of human heart
Frontiers in Physiology, 2023 Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology.
Hanna Vuorenpää +17 more
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In silico signaling modeling to understand cancer pathways and treatment responses
, 2022 S.1115-1117Precision medicine has changed thinking in cancer therapy, highlighting a better understanding of the individual clinical interventions. But what role do the drivers and pathways identified from pan-cancer genome analysis play in the tumor? In
Nietzer, Sarah +8 more
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