Results 31 to 40 of about 114,431,160 (255)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]

, 2013
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
Vodovotz, Yoram, Derek Barclay, Ruben Zamora, Zamora, R, Bartels John, Billiar, TR, Yoram Vodovotz (59974), Billiar Timothy R., Rami A Namas, Vodovotz, Y, Derek Barclay (258485), Bartels, John, Rosemary Hoffman, Rami A. Namas, Barclay, Derek, Ruben Zamora (221654), Hoffman, Rosemary, Rami A. Namas (429290), Hoffman Rosemary, Billiar, Timothy R., Rosemary Hoffman (429291), Zamora Ruben, Timothy R Billiar, Namas Rami A., Yoram Vodovotz, Barclay Derek, Namas, RA, John Bartels (377805), Timothy R. Billiar (91972), Vodovotz Yoram, John Bartels, Namas, Rami A, Timothy R. Billiar, Zamora, Ruben, Hoffman, R, Barclay, D, Bartels, J   +36 more
core   +2 more sources

Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein

Journal of Genetic Engineering and Biotechnology, 2020
Background Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches.
Afnan Saleem, Shiveeli Rajput
doaj   +1 more source

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Frontiers in Physiology, 2023
Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology.
Hanna Vuorenpää, Hanna Vuorenpää, Hanna Vuorenpää, Miina Björninen, Miina Björninen, Miina Björninen, Hannu Välimäki, Hannu Välimäki, Antti Ahola, Antti Ahola, Mart Kroon, Mart Kroon, Laura Honkamäki, Laura Honkamäki, Jussi T. Koivumäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila, Mari Pekkanen-Mattila   +17 more
doaj   +1 more source

"In silico" prediction of drug transport across physiological barriers [PDF]

, 2011
Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
core   +1 more source

In vitro and in silico Approaches to the Identification of New Compounds with Antibacterial Profile [PDF]

Journal of Systemics, Cybernetics and Informatics, 2013
The emergence of multidrug-resistant bacterial strains is a world problem that increases the need for new and more effective antimicrobials. On that purpose, derivatives of cyclic systems may serve as new leads for discovering new active molecules.
Carlos R. Rodrigues, Bruno Leal, Kely N. De Oliveira, Ariane S. S. R. Ferreira, Alice Bernardino, Ricardo J. Nunes, Vitor Ferreira, Maria C. De Souza, Anna C. Cunha, Helena C. Castro   +9 more
doaj  

Potential inhibitors of VEGFR1, VEGFR2, and VEGFR3 developed through Deep Learning for the treatment of Cervical Cancer

Scientific Reports
Cervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show ...
Anuraj Nayarisseri, Mohnad Abdalla, Isha Joshi, Manasi Yadav, Anushka Bhrdwaj, Ishita Chopra, Arshiya Khan, Arshiya Saxena, Khushboo Sharma, Aravind Panicker, Umesh Panwar, Francisco Jaime Bezerra Mendonça Junior, Sanjeev Kumar Singh   +12 more
doaj   +1 more source

Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach

Molecules, 2022
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad, Ali Zari, Nouf H. Alsubhi, Maryam H. Al-Zahrani, Rana Abdullah Alghamdi, Mai M. Labib   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Biodegradation of plasticizers by novel strains of bacteria isolated from plastic waste near Juhu Beach, Mumbai, India

Scientific Reports
Phthalic acid esters are pivotal plasticizers in various applications, including cosmetics, packaging materials, and medical devices. They have garnered significant attention from the scientific community due to their persistence in ecosystems.
Khushboo Sharma, Anuraj Nayarisseri, Sanjeev Kumar Singh   +2 more
doaj   +1 more source

CDR1 Composition Can Affect Nanobody Recombinant Expression Yields

Biomolecules, 2021
The isolation of nanobodies from pre-immune libraries by means of biopanning is a straightforward process. Nevertheless, the recovered candidates often require optimization to improve some of their biophysical characteristics.
Marco Orlando, Sara Fortuna, Sandra Oloketuyi, Gregor Bajc, Adi Goldenzweig, Ario de Marco   +5 more
doaj   +1 more source