Results 11 to 20 of about 93,106 (305)

Structural Equation Modeling of In silico Perturbations [PDF]

Frontiers in Genetics, 2021
Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Jianying Li, Jianying Li, Jianying Li, Pierre R. Bushel, Pierre R. Bushel, Lin Lin, Lin Lin, Kevin Day, Tianyuan Wang, Tianyuan Wang, Francesco J. DeMayo, San-Pin Wu, Jian-Liang Li   +12 more
openaire   +6 more sources

In Silico 3D Modeling of Binding Activities

, 2016
In silico three-dimensional (3D) molecular modeling tools based upon the receptor/enzyme-ligand docking simulation in protein crystal structures and/or homology modeling of receptors have been reliably used in pharmacological research and development for decades.
MORO, STEFANO, STURLESE, MATTIA, CIANCETTA, ANTONELLA, Floris, Matteo   +3 more
openaire   +5 more sources

Multiscale In Silico Modeling of Cartilage Injuries

, 2023
AbstractInjurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which mechanism controls further cartilage degradation, ultimately leading to post-traumatic osteoarthritis.
Eskelinen Atte Seppo Aleksi, Esrafilian Amir, Florea Cristina, Orozco Grajales Gustavo Alejandro, Tanska Petri Kalevi, Korhonen Rami Kristian   +5 more
openaire   +3 more sources

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Drug Design, Development and Therapy, 2016
Fidele Ntie-Kang,1,2,* Conrad Veranso Simoben,1,2,* Berin Karaman,1 Valery Fuh Ngwa,3 Philip Neville Judson,4 Wolfgang Sippl,1 Luc Meva’a Mbaze5 1Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle (Saale ...
Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM   +6 more
doaj   +1 more source

BCNNM: A Framework for in silico Neural Tissue Development Modeling [PDF]

, 2021
Cerebral (“brain”) organoids are high-fidelity in vitro cellular models of the developing brain, which makes them one of the go-to methods to study isolated processes of tissue organization and its electrophysiological properties, allowing to collect ...
Kolchanova, Sofiia M.,, Stelmakh, Viktoriia A., Polovian, Aleksandr I., Schiöth, Helgi B., Bozhko, Dmitrii V., Polovian, Aleksandr I.,, Myrov, Vladislav O., Myrov, Vladislav O.,, Schiöth, Helgi B.,, Stelmakh, Viktoriia A.,, Kolchanova, Sofiia M., Bozhko, Dmitrii V.,, Galumov, Georgii K., Galumov, Georgii K.,   +13 more
core   +1 more source

In silico experimental modeling of cancer treatment [PDF]

, 2012
In silico experimental modeling of cancer involves combining findings from biological literature with computer-based models of biological systems in order to conduct investigations of hypotheses entirely in the computer laboratory.
Trisilowati, Mallet, Daniel G.
core   +1 more source

The acceptance of in silico models for REACH: Requirements, barriers, and perspectives [PDF]

, 2011
In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes.
Antonio Cassano, R. Gonella Diaza, Giuseppina Gini, Simon Pardoe, Rodolfo Gonella Diaza, Rodolfo Diaza, Knauf Ralf, Pardoe, Simon, Benighaus, Ludger, L. Benighaus, Cassano Antonio, A. Cassano, E. Benfenati, Mays, Claire, S. Pardoe, C. Mays, Ludger Benighaus, R. Knauf, Ralf Knauf, Benighaus Ludger, Gini Giuseppina, Emilio Benfenati, Knauf, Ralf, Claire Mays, Mays Claire, Benfenati Emilio, Gini, Giuseppina, Diaza Rodolfo, Gonella Diaza, Rodolfo, Cassano, Antonio, Benfenati, Emilio, Pardoe Simon   +31 more
core   +1 more source

A clinically aligned experimental approach for quantitative characterization of patient-specific cardiovascular models

AIP Advances, 2020
Recent improvements in computational tools opened the possibility of patient-specific modeling to aid clinicians during diagnosis, treatment, and monitoring. One example is the modeling of blood flow for surgical planning, where modeling can help predict
Ana Paula Narata, Fernando Silva de Moura, Fréderic Patat, Alberto Marzo, Ignacio Larrabide, Jean-Marc Gregoire, Cecile Perrault, Charles A. Sennoga, Ayache Bouakaz   +8 more
doaj   +1 more source

Editorial: Multiscale cancer modeling, in silico oncology and digital (virtual) twins in the cancer domain

Frontiers in Physiology
Georgios S. Stamatakos, Maria Angeles Perez, Ravi Radhakrishnan   +2 more
doaj   +3 more sources

In silico models of cancer [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractCancer is a complex disease that involves multiple types of biological interactions across diverse physical, temporal, and biological scales. This complexity presents substantial challenges for the characterization of cancer biology, and motivates the study of cancer in the context of molecular, cellular, and physiological systems ...
Lucas B, Edelman, James A, Eddy, Nathan D, Price   +2 more
openaire   +2 more sources