Results 21 to 30 of about 167,809 (296)
In Silico Models for Drug Resistance [PDF]
, 2013 Resistance to drugs that treat infectious disease is a major problem worldwide. The rapid emergence of drug resistance is not well understood. We present two in silico models for the discovery of drug resistance mechanisms and for combating the evolution of resistance, respectively.
Fatumo, S. +2 more
openaire +3 more sources
Structural Equation Modeling of In silico Perturbations [PDF]
Frontiers in Genetics, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Jianying Li +12 more
openaire +5 more sources
Proceedings, 2019 TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]
Lena Trifonov +9 more
doaj +1 more source
In Silico Models for Ecotoxicity of Pharmaceuticals [PDF]
, 2016 Pharmaceuticals and their active metabolites are one of the significantly emerging environmental toxicants. The major routes of entry of pharmaceuticals into the environment are industries, hospitals, or direct disposal of unwanted or expired drugs made by the patient.
Roy, Kunal, Kar, Supratik
openaire +2 more sources
Semantically Linking in Silico Cancer Models [PDF]
Cancer Informatics, 2014 Multiscale models are commonplace in cancer modeling, where individual models acting on different biological scales are combined within a single, cohesive modeling framework. However, model composition gives rise to challenges in understanding interfaces and interactions between them.
Johnson, D +6 more
openaire +6 more sources
Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core +7 more sources
Molecules, 2022 Molecular modeling approaches are used in a versatile way to investigate the properties of diverse organic and inorganic structures such as proteins, biomolecules, nanomaterials, functionalized nanoparticles, and membranes. However, more detailed studies
Jorddy Neves Cruz +3 more
doaj +1 more source
Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. [PDF]
, 2013 A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various
Hunt, C. Anthony +4 more
core +2 more sources
Ethics in autonomous robots as philosophy in silico: The study case of phronetic machine ethics
Logos i Ethos, 2020 The paper explores the application of computing science to the modeling of the ethical concepts. The modeling in computers is denoted as in silico modeling.
Paweł Polak, Roman Krzanowski
doaj +1 more source
In silico modeling in infectious disease
Drug Discovery Today: Disease Models, 2007 Infectious disease has witnessed the emergence of mathematical modeling a tool of synthesizing data of growing complexity now available to clinicians and basic scientists alike. The purpose of this review is to introduce mathematical tools commonly used to model infectious disease.
Daun, Silvia, Clermont, Gilles
openaire +2 more sources