Results 1 to 10 of about 114,431,160 (255)
Structural Equation Modeling of In silico Perturbations [PDF]
Frontiers in Genetics, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Pierre Bushel +2 more
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Frontiers in Physiology, 2023 Intracardiac electrograms (iEGMs) are time traces of the electrical potential recorded close to the heart muscle. We calculate unipolar and bipolar iEGMs analytically for a myocardial slab with parallel myofibers and validate them against numerical ...
Lore Leenknegt +4 more
doaj +1 more source
Application in silico Modeling Simulation in Bioequivalence Studies: A Review
Journal of Food and Pharmaceutical Sciences, 2023 Bioequivalence testing aims to ensure that the therapeutic performance of the drug is consistent and reproducible when it is administrated. Modeling and simulation in silico methods are currently performed to conduct virtual bioequivalence studies ...
Sekar Ayu Pawestri
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In Silico Hemostasis Modeling and Prediction [PDF]
Hämostaseologie, 2020 AbstractComputational physiology, i.e., reproduction of physiological (and, by extension, pathophysiological) processes in silico, could be considered one of the major goals in computational biology. One might use computers to simulate molecular interactions, enzyme kinetics, gene expression, or whole networks of biochemical reactions, but it is (patho)
Dmitry Y, Nechipurenko +3 more
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Plant catalase in silico characterization and phylogenetic analysis with structural modeling
Journal of Genetic Engineering and Biotechnology, 2022 Background Catalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It was the first enzyme to be crystallized and isolated. Catalase is a well-known industrial enzyme used in
Takio Nene +2 more
doaj +1 more source
Critical Care Medicine, 2013 To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.PubMed search and review of relevant medical literature.Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole ...
Yoram, Vodovotz, Timothy R, Billiar
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Modeling Neurodegeneration in silico With Deep Learning [PDF]
Frontiers in Neuroinformatics, 2021 Deep neural networks, inspired by information processing in the brain, can achieve human-like performance for various tasks. However, research efforts to use these networks as models of the brain have primarily focused on modeling healthy brain function so far.
Anup Tuladhar +13 more
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In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable
Trials, 2021 Imaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability.
Aldo Badano
doaj +1 more source
Drug Delivery, 2022 Transdermal fentanyl patches are an effective alternative to the sustained release of oral morphine for chronic pain management. Due to the narrow therapeutic range of fentanyl, the concentration of fentanyl in the blood needs to be carefully monitored ...
Flora Bahrami +2 more
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In silico models of cancer [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractCancer is a complex disease that involves multiple types of biological interactions across diverse physical, temporal, and biological scales. This complexity presents substantial challenges for the characterization of cancer biology, and motivates the study of cancer in the context of molecular, cellular, and physiological systems ...
Lucas B, Edelman +2 more
openaire +2 more sources