Results 191 to 200 of about 32,158 (205)

Cystatin from Austrelaps superbus snake venom as a model for identifying potential inhibitors of Trypanosoma cruzi cruzain. [PDF]

J Venom Anim Toxins Incl Trop Dis
Díaz JJAR, Garay AFG, Kayano AM, Holanda R, Francisco AF, Kuehn CC, Soares AM, Vega C, Calderon LA.   +8 more
europepmc   +1 more source

Network Analysis to Identify MicroRNAs Involved in Alzheimer's Disease and to Improve Drug Prioritization. [PDF]

Biomedicines
Reyna A, Panni S.
europepmc   +1 more source

Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. [PDF]

Bioorg Med Chem Lett
Frost GB, Liu Y, Kron SJ, Scheidt KA.
europepmc   +1 more source

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RETRACTED: In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation

Environmental Research, 2022
Fish skin collagen hydrolyzate has demonstrated the potent inhibition of dipeptidyl peptidase-IV (DPP-IV), one of the treatments for type-2 diabetes mellitus (type-2 DM), but the precise mechanism is still unclear. This study used in silico method to evaluate the potential of the active peptides from tilapia skin collagen (Oreochromis niloticus) for ...
Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Jerlita Dea Berliana, Siti Aisyah, Vidia Afina Nuraini, Andriati Ningrum, Eko Susanto, Larasati Martha, Isman Kurniawan, Nur Akmalia Hidayati, Apurav Krishna Koyande, Pau-Loke Show   +11 more
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Yak milk casein as potential precursor of angiotensin I-converting enzyme inhibitory peptides based on in silico proteolysis

Food Chemistry, 2018
Yak milk casein was selected as a potential precursor of bioactive peptides based on in silico analysis. Most notable among these are the angiotensin I-converting enzyme (ACE) inhibitory peptides. First, yak milk casein has high homology with cow milk casein by homologous analysis.
Kai, Lin, Lan-Wei, Zhang, Xue, Han, Liang, Xin, Zhao-Xu, Meng, Pi-Min, Gong, Da-You, Cheng   +6 more
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Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design

Cancer Chemotherapy and Pharmacology, 2019
The human peroxiredoxin-5 (hPRDX5) is a member of the family of antioxidant enzymes, which could resist immunosuppression by promoting immune organs development, lymphocyte proliferation and up-regulation of the levels of serum cytokines. However, being a recombinant protein, the hPRDX5 exhibits some problems including the high production cost and bad ...
Sen, Zou, Juanjuan, Liu, Zhengyang, Sun, Xiao, Feng, Zhongbo, Wang, Yuanyuan, Jin, Zhaoyong, Yang   +6 more
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In silico analysis of amino acid biosynthesis and proteolysis in Lactobacillus delbrueckii subsp. bulgaricus 2038 and the implications for bovine milk fermentation

Biotechnology Letters, 2012
The amino acid biosynthesis pathway and proteolytic system of Lactobacillus delbrueckii subsp. bulgaricus 2038 (L. bulgaricus 2038), a mainstay of large-scale yogurt production, were modeled based on its genomic sequence. L. bulgaricus 2038 retains more potential for amino acid synthesis and a more powerful proteolytic system than other L.
Huajun, Zheng, Enuo, Liu, Pei, Hao, Tomonobu, Konno, Munehiro, Oda, Zai-Si, Ji   +5 more
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Computational methods and key considerations for in silico design of proteolysis targeting chimera (PROTACs)

International Journal of Biological Macromolecules
Proteolysis-targeting chimeras (PROTACs), as heterobifunctional molecules, have garnered significant attention for their ability to target previously undruggable proteins. Due to the challenges in obtaining crystal structures of PROTAC molecules in the ternary complex, a plethora of computational tools have been developed to aid in PROTAC design. These
Amr, Abbas, Fei, Ye
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Initial proteolysis of milk proteins and its effect on formation of ACE-inhibitory peptides during gastrointestinal proteolysis: a bioinformatic, in silico, approach

European Food Research and Technology, 2005
Angiotensin-I-converting enzyme (ACE)-inhibitory peptides are encrypted in milk protein sequences. They may express an antihypertensive effect if they are released by proteolysis in foods and/or during gastrointestinal digestion. A bioinformatic, in silico, approach was developed to evaluate how systematic initial proteolysis, i.e.
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