Results 91 to 100 of about 84,932 (303)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Conservation Status and Current Distribution of Endemic and Extinction-Prone Bellevalia edirnensis Özhatay & Mathew (Asparagaceae)

Trakya University Journal of Natural Sciences, 2015
In this study, current distribution, population status and the threats on the habitat of the endemic and endangered species Bellevalia edirnensis were investigated.
Sergun DAYAN, Necmettin GÜLER, Hayati ARDA, Adnan ÇOLAK, Ayhan AYTAÇ   +4 more
doaj   +6 more sources

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Black Stork Down: Military Discourses in Bird Conservation in Malta [PDF]

, 2015
Tensions between Maltese hunters and bird conservation NGOs have intensified over the past decade. Conservation NGOs have become frustrated with the Maltese State for conceding to the hunter lobby and negotiating derogations from the European Union’s ...
Veríssimo, Diogo, Campbell, Brian
core   +1 more source

Livestock Germplasm Resource Conservation in China: Current Status and Prospect [PDF]

中国工程科学
Livestock germplasm resources are a strategic foundation for sustainable agricultural development, food security, and biodiversity conservation. Their security status directly influences the development of the livestock industry and the safety of the ...
Yefang Li, Yanfang Su, Jing Wang, Xinhua Wei, Wenxuan Zhao, Dawei Yu, Yanyan Sun, Yaxiong Jia, Yuehui Ma, Shuisheng Hou, Lin Jiang   +10 more
doaj   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Scientific background of ex-situ conservation and reintroduction of endemic plant species Minuartia smejkalii [PDF]

, 2018
Ex-situ conservation and species reintroduction is a standard approach in many conservation actions. These actions should ensure that the new populations will be genetically diverse and will not suffer from loss of fitness due to inbreeding or ...
Mária Šurinová, Bojana Stojanova, Stojanova, Bojana, Zuzana Münzbergová, Pánková, Hana, Šurinová, Mária, Hana Pánková, Münzbergová, Zuzana   +7 more
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Farmers' Use of Improved Seed Selection Practices in Mexican Maize: Evidence and Issues from the Sierra de Santa Marta [PDF]

The principal advantage of in situ conservation is that it allows adaptive evolutionary processes to continue in the species that are being conserved. For a cultivated crop species, in situ conservation involves farmers' management of their own genetic ...
Blanco, Jose-Luis, Rice, Elizabeth, Smale, Melinda   +2 more
core   +1 more source

Diversidade de variedades de milho comum conservadas In situ - On farm no município de Novo Horizonte - SC [PDF]

, 2013
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Agroecossistemas, Florianópolis, 2013.A ameaça constante da perda de Variedades Crioulas e locais de milho comum está ...
Triches, Marcio
core