Results 201 to 210 of about 68,322 (257)

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

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Quasi in situ: a bridge between ex situ and in situ conservation of plants

Biodiversity and Conservation, 2010
Plant conservation urgently needs a concept that would unify different aspects of population viability as parts of conservation methodology. Such unification is especially lacking for ex situ conservation. We introduce a novel conservation approach in which ex situ collections maintained in natural or semi-natural environment and preserving both ...
Sergei Volis
exaly   +2 more sources

CONSERVATION CHALLENGES AND IN SITU AND EX SITU APPROACHES TO REPTILE CONSERVATION

2022
Not ...
Crottini, A., Gardner, C. J., Pedrono, M., Jenkins, R. K. B., Behra, O., Ramy, A., Raxworthy, C. J.   +6 more
openaire   +4 more sources

Conservative Management of Adenocarcinoma in Situ of the Cervix

Gynecologic Oncology, 2000
The purpose of this study was to determine the method of treatment and outcome of women with cervical adenocarcinoma in situ (AIS).Following institutional review board approval, all women diagnosed with cervical AIS from 1987 to 1999 were identified. Data were retrospectively collected by record review and correspondence with medical providers.Of 132 ...
C H, Shin, J O, Schorge, K R, Lee, E E, Sheets   +3 more
openaire   +2 more sources

In Situ Conservation

2017
This chapter focuses on in situ conservation. First, it defines in situ conservation and explains that it covers numerous active management techniques. The chapter looks at the aims of in situ management, which range from creating, restoring, protecting, and maintaining to improving and connecting.
Anne E. Goodenough, Adam G. Hart
openaire   +1 more source

In Situ Conservation

2001
The Mediterranean Basin, especially the coastline and the semi-arid and arid rangelands, have in the recent past and are currently suffering acutely from human activities that result in genetic erosion. As discussed in earlier chapters, these activities include: increasing industrialization, pollution, urbanization, inadvertent fires, increasing ...
Nigel Maxted, Ayfer Tan, Ahmed Amri, Jan Valkoun   +3 more
openaire   +1 more source

Ex Situ Conservation

2017
This chapter looks into ex situ conservation. It acknowledges that in situ conservation techniques might be needed if a successful ex situ conservation programme, which is termed reintroduction, is achieved. The chapter explores the subdivisions of ex situ conservation: intensive or general captive breeding programmes and gene banks.
Anne E. Goodenough, Adam G. Hart
openaire   +1 more source