Results 211 to 220 of about 70,838 (262)

Maintaining the native gut microbiota of bharal (Pseudois nayaur) is crucial in ex situ conservation. [PDF]

Front Microbiol
Gao H, Chi X, Song P, Gu H, Xu B, Cai Z, Jiang F, Li B, Zhang T.   +8 more
europepmc   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

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CONSERVATION CHALLENGES AND IN SITU AND EX SITU APPROACHES TO REPTILE CONSERVATION

2022
Not ...
Crottini, A., Gardner, C. J., Pedrono, M., Jenkins, R. K. B., Behra, O., Ramy, A., Raxworthy, C. J.   +6 more
openaire   +4 more sources

Conservative Management of Adenocarcinoma in Situ of the Cervix

Gynecologic Oncology, 2000
The purpose of this study was to determine the method of treatment and outcome of women with cervical adenocarcinoma in situ (AIS).Following institutional review board approval, all women diagnosed with cervical AIS from 1987 to 1999 were identified. Data were retrospectively collected by record review and correspondence with medical providers.Of 132 ...
C H, Shin, J O, Schorge, K R, Lee, E E, Sheets   +3 more
openaire   +2 more sources

In Situ Conservation

2017
This chapter focuses on in situ conservation. First, it defines in situ conservation and explains that it covers numerous active management techniques. The chapter looks at the aims of in situ management, which range from creating, restoring, protecting, and maintaining to improving and connecting.
Anne E. Goodenough, Adam G. Hart
openaire   +1 more source

In Situ Conservation

2001
The Mediterranean Basin, especially the coastline and the semi-arid and arid rangelands, have in the recent past and are currently suffering acutely from human activities that result in genetic erosion. As discussed in earlier chapters, these activities include: increasing industrialization, pollution, urbanization, inadvertent fires, increasing ...
Nigel Maxted, Ayfer Tan, Ahmed Amri, Jan Valkoun   +3 more
openaire   +1 more source

In Situ and Ex Situ Conservation of Chinese Plants

2020
In total, 28,385 higher plants were distributed in the nature reserves, accounting for 77.0% of the total number of higher plants in China. Among them, there are 3842 species which are effectively protected; 2478 species are better protected. More than 84.4% endangered species grow in national and/or provincial natural reserves.
Xiaohua Jin, Hai Ren
openaire   +1 more source