Results 51 to 60 of about 26,404 (336)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Shape‐Morphing Nanoengineered Hydrogel Ribbons as Hemostats

Advanced Functional Materials, EarlyView.
This study introduces a self‐assembling, shape‐morphing nanoengineered hydrogel ribbon system that rapidly forms porous aggregates in situ for efficient hemostasis in trauma and surgical applications. Abstract Rapid and effective hemorrhage control remains a major challenge in trauma and surgical care, particularly for complex or noncompressible wounds.
Ryan Davis Jr, Saptarshi Biswas, Jacob Aragon, Asaf Dana, Jasmine Sureka, Vaaridhi Ramanuja, Jeevika Thazhaiselvam, Sarah E. Miller, Taylor H. Ware, Akhilesh K. Gaharwar   +9 more
wiley   +1 more source

The absorption of oral morroniside in rats: In vivo, in situ and in vitro studies

Acta Pharmaceutica, 2019
Morroniside is one of the most important iridoid glycosides from Cornus officinalis Sieb. et Zucc. In the present study, the pharmacokinetics and bioavailability studies of morroniside were conducted on Sprague-Dawley (SD) rats.
Xiong Shan, Li Jinglai, Mu Yanling, Zhang Zhenqing   +3 more
doaj   +1 more source

Efeitos hemodinâmicos e metabólicos iniciais da perfusão hipotérmica intestinal in situ.: avaliação de um novo modelo canino de autotransplante intestinal Initial hemodynamic and metabolic effects of intestinal hypothermic perfusion in situ: an alternative model of canine intestinal autotransplantation

Acta Cirúrgica Brasileira, 2004
O transplante intestinal tem sido utilizado como uma alternativa promissora no tratamento da síndrome do intestino curto em pacientes adultos e pediátricos.
Ruy Jorge Cruz Junior, Cristiano de Jesus Correia, Luiz Francisco Poli de Figueiredo, Maurício Rocha e Silva   +3 more
doaj   +1 more source

Computer-assisted ex vivo, normothermic small bowel perfusion [PDF]

, 2000
Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena.
Eder, M., Hammer, C., Krapp, J., Land, W., Schildberg, Friedrich Wilhelm, Stangl, M. J., Theodorou, D.   +6 more
core   +1 more source

MAGTWIST: A Magnetically‐Driven Rotary Actuator Using a Traveling‐Wave With Integrated Stiffness Tunability

Advanced Functional Materials, EarlyView.
MAGTWIST: A compact magnetic rotary actuator, enabling smooth, stepless rotation, and on‐demand locking. Inspired by peristalsis, a soft polymer belt generates a traveling‐wave, enabling 270° rotation when heated. Cooling stiffens the belt, locking it in position and enabling it to withstand high loads.
Simon Frieler, Jean‐Paul P.M. de Vries, Sarthak Misra, Venkatasubramanian Kalpathy Venkiteswaran   +3 more
wiley   +1 more source

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Pharmaceutics, 2020
An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs.
Juliane Fjelrad Christfort, Antonio José Guillot, Ana Melero, Lasse Højlund Eklund Thamdrup, Teresa M. Garrigues, Anja Boisen, Kinga Zór, Line Hagner Nielsen   +7 more
doaj   +1 more source

Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.
Yang Liu, Jing Sun, Linying Zhong, Yu Li, A Na Er, Tong Li, Le Yang, Ling Dong   +7 more
doaj   +1 more source

Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model

Biomedicine & Pharmacotherapy, 2018
Araloside A is a triterpenoid saponin,which exhibits a broad spectrum of pharmacological activities, such as stimulating fibrinolysis, preventing coagulant, inhibiting renin, and decreasing blood pressure. Our previous report found that the compound exhibits a poor absolute bioavailability.
Hui, Yang, Bingtao, Zhai, Yu, Fan, Jing, Wang, Jing, Sun, Yajun, Shi, Dongyan, Guo   +6 more
openaire   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source