Results 61 to 70 of about 11,428 (247)

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies [PDF]

, 2018
This paper presents the design and fabrication of a multi-layer and multi-chamber microchip system using thiol-ene 'click chemistry' aimed for drug transport studies across tissue barrier models. The fabrication process enables rapid prototyping of multi-
Andresen, Thomas Lars, Dufva, Martin, Kutter, Jörg Peter, Rahbek, Ulrik L, Tan, Hsih-Yin, Trier, Sofie   +5 more
core   +3 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol). [PDF]

, 2006
Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound.
Amidon, G L, Barends, Dirk M, Dressman, J B, Junginger, H E, Kalantzi, L, Midha, K K, Reppas, C, Shah, V P, Stavchansky, S A   +8 more
core   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

International Journal of Nanomedicine, 2022
Shan Huang,1 Bingtao Zhai,1 Yu Fan,2 Jing Sun,1 Jiangxue Cheng,1 Junbo Zou,1 Xiaofei Zhang,1 Yajun Shi,1 Dongyan Guo1 1Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of ...
Huang S, Zhai B, Fan Y, Sun J, Cheng J, Zou J, Zhang X, Shi Y, Guo D   +8 more
doaj  

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Bioreactor technologies to support liver function in vitro [PDF]

, 2014
Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics.
Aitken, Allen, Allen, Ananthanarayanan, Baranski, Baudoin, Baudoin, Billiet, Biswas, Buck, Buechler, Carpentier, Carraro, Chen, Chung, Cogger, Commandeur, Cosgrove, Cosgrove, Crispe, Daly, Darnell, Dash, Dash, David J. Hughes, De Bartolo, De Bartolo, Demetriou, Derby, Detry, Detzel, Dhir, Di, Di, Di Paolo, Dich, Dickmann, Dickmann, Domansky, Ebrahimkhani, Ebrahimkhani, Eckhardt, Edwards, Elferink, Faber, Fang, Feng, Flendrig, Foulkes, Friedman, Friedman, Gao, Gebhardt, Gerlach, Godoy, Goral, Goral, Greer, Griffin, Griffith, Griffith, Griffith, Gripon, Guarner, Guzzardi, Hadi, Haibe-Kains, Halilbasic, Hang, Hellman, Hoekstra, Hoffmann, Hofmann, Hwa, Höchst, Inamdar, Inman, International Transporter Consortium, Jaclyn A. Shepard Neiman, Jakoby, Jauregui, Jauregui, Kan, Kan, Kane, Khetan, Kim, Klein, Knazek, Knolle, Knolle, Kostadinova, Lalor, Lau, Lautt, Leclerc, Leclerc, Leclerc, LeCluyse, Lee, Lee, Legendre, Liaskou, Liddle, Lillegard, Linda G. Griffith, Loryan, Lozoya, Lumsden, Lutolf, Lynch, Lübberstedt, Lübberstedt, Mackay, Mareels, Marion, Mazzei, McGraw, Mehta, Micha Sam B. Raredon, Mironov, Mironov, Mohammad R. Ebrahimkhani, Nahmias, Nibourg, Nibourg, Nishikawa, Novik, Nyberg, O'Brien, O'Hara, Ohtani, Olsen, Olson, Ong, Ostrovidov, Ouattara, Panesar, Park, Perogamvros, Planchamp, Pless, Polakos, Powers, Powers, Powers, Powers, Poyck, Poyck, Poyck, Poyck, Prot, Prot, Prot, Prot, Regehr, Rehermann, Reid, Ring, Rozga, Rozga, Rozga, Rutzky, Sauer, Schmelzer, Schmitt, Schumacher, Schuppan, Seki, Sewer, Shuler, Shulla, Sin, Sivaraman, Steenbergen, Stimson, Struecker, Sudo, Sung, Sung, Sung, Sung, Sung, Sussman, Taguchi, Tanaka, Tang, Tapia, Tilles, Toh, Toh, Tostões, Turner, Uchino, van Midwoud, van Midwoud, van Midwoud, van Midwoud, van Midwoud, van Midwoud, van Midwoud, Vander Heiden, Verhulsel, Vinci, Viravaidya, Vozzi, Wack, Wagner, Wagner, Wang, Wang, Warkiani, Waxman, Wiig, Williams, Wilson, Wolf, Wu, Xia, Xia, Xia, Xu, Xu, Yamada, Yates, Zeilinger, Zeilinger, Zhang, Zhang, Zhang   +229 more
core   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Indocyanine green fluorescence imaging in colorectal surgery: overview, applications, and future directions [PDF]

, 2017
Indocyanine green fluorescence imaging is a surgical tool with increasing applications in colorectal surgery. This tool has received acceptance in various surgical disciplines as a potential method to enhance surgical field visualisation, improve lymph ...
Chand, M, Cohen, R, Ishizawa, T, Keller, DS   +3 more
core   +1 more source